Τίτλος:
Bronchiectasis exacerbations: The role of atypical bacteria and respiratory syncytial virus
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Aside from the known role of common bacteria, there is a paucity of data regarding the possible role of atypical bacteria and viruses in exacerbations of non-cystic fibrosis bronchiectasis. objective: To explore the possible role of atypical bacteria (namely, Mycoplasma pneumoniae and Chlamydophila pneumoniae) and respiratory syncytial virus (RSV) as causative agents of bronchiectasis exacerbations. Methods: A cohort of 33 patients was studied over a two-year period (one year follow-up for each patient). Polymerase chain reaction for the detection of M pneumoniae, C pneumoniae and RSV in bronchoalveolar lavage samples were performed during all visits. Antibody titres (immunoglobulin [Ig]M and IgG) against the aforementioned pathogens were also measured. In addition, cultures for common bacteria and mycobacteria were performed from the bronchoalveolar lavage samples. Results : Fifteen patients experienced a total of 19 exacerbations during the study period. Although RSV was detected by polymerase chain reaction during stable visits in four patients, it was never detected during an exacerbation. M pneumoniae and C pneumoniae were never detected at stable visits or during exacerbations. IgM antibody titres for these three pathogens were negative in all patient visits. Conclusions: Atypical pathogens and RSV did not appear to be causative agents of bronchiectasis exacerbations. © 2015 Pulsus Group Inc. All rights reserved.
Συγγραφείς:
Metaxas, E.I.
Balis, E.
Papaparaskevas, J.
Spanakis, N.E.
Tatsis, G.
Tsakris, A.
Περιοδικό:
Canadian Respiratory Journal
Εκδότης:
Pulsus Group Inc.
Λέξεις-κλειδιά:
antibiotic agent; immunoglobulin G; immunoglobulin M; immunoglobulin M antibody, adult; antibody titer; Article; bacterium detection; bronchiectasis; Chlamydophila pneumoniae; clinical article; cohort analysis; disease exacerbation; female; follow up; human; Human respiratory syncytial virus; lung lavage; male; Mycobacterium; Mycoplasma pneumoniae; pathogenesis; polymerase chain reaction; priority journal; serology; bronchiectasis; bronchoalveolar lavage fluid; Chlamydia pneumoniae; Human respiratory syncytial virus; isolation and purification; lung function test; microbiology; Mycoplasma pneumoniae; virology, Adult; Bronchiectasis; Bronchoalveolar Lavage Fluid; Chlamydophila pneumoniae; Cohort Studies; Female; Humans; Male; Mycoplasma pneumoniae; Respiratory Function Tests; Respiratory Syncytial Viruses
