Τίτλος:
Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: A systematic review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) has been demonstrated in several cancers, but its prognostic role is unknown. We aimed to investigate the risk associated with loss of ARID1A (ARID1A-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS search from database inception until 01/31/2015 without language restriction was conducted, contacting authors for unpublished data. Eligible were prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of ARID1A (ARID1A+) vs. ARID1A-, assessed either via immunohistochemistry (loss of expression) or with genetic testing (presence of mutation). Data were summarized using risk ratios (RR) for number of deaths/recurrences and hazard ratios (HR) for time-dependent risk related to ARID1A- adjusted for potential confounders. Of 136 hits, 25 studies with 5,651 participants (28 cohorts; ARID1A-: n = 1,701; ARID1A+: n = 3,950), with a mean follow-up period of 4.7 ± 1.8 years, were meta-analyzed. Compared to ARID1A+, ARID1A- significantly increased cancer-specific mortality (studies = 3; RR = 1.55, 95% confidence interval (CI) = 1.19-2.00, I2 = 31%). Using HRs adjusted for potential confounders, ARID1A- was associated with a greater risk of cancer-specific mortality (studies = 2; HR = 2.55, 95%CI = 1.19-5.45, I2 = 19%) and cancer recurrence (studies = 10; HR = 1.93, 95%CI = 1.22-3.05, I2 = 76%). On the basis of these results, we have demonstrated that loss of ARID1A shortened time to cancer-specific mortality, and to recurrence of cancer when adjusting for potential confounders. For its role, this gene should be considered as an important potential target for personalized medicine in cancer treatment.
Συγγραφείς:
Luchini, C.
Veronese, N.
Solmi, M.
Cho, H.
Kim, J.-H.
Chou, A.
Gill, A.J.
Faraj, S.F.
Chaux, A.
Netto, G.J.
Nakayama, K.
Kyo, S.
Lee, S.Y.
Kim, D.-W.
Yousef, G.M.
Scorilas, A.
Nelson, G.S.
Köbel, M.
Kalloger, S.E.
Schaeffer, D.F.
Yan, H.-B.
Liu, F.
Yokoyama, Y.
Zhang, X.
Pang, D.
Lichner, Z.
Sergi, G.
Manzato, E.
Capelli, P.
Wood, L.D.
Scarpa, A.
Correll, C.U.
Περιοδικό:
OncoTargets and therapy
Εκδότης:
Impact Journals, LLC
Λέξεις-κλειδιά:
ARID1A gene; Article; cancer mortality; cancer prognosis; cancer recurrence; cancer staging; digestive system cancer; disease association; female genital tract cancer; gene function; gene mutation; genetic screening; geographic origin; human; immunohistochemistry; risk; sex difference; survival rate; systematic review; tumor suppressor gene; urinary tract cancer; cohort analysis; female; genetics; male; meta analysis; middle aged; mutation; neoplasm; prognosis, ARID1A protein, human; nuclear protein; transcription factor, Cohort Studies; Female; Genes, Tumor Suppressor; Humans; Male; Middle Aged; Mutation; Neoplasms; Nuclear Proteins; Prognosis; Transcription Factors
DOI:
10.18632/oncotarget.5142
