Τίτλος:
The impact of aerobic exercise training on novel adipokines, apelin and ghrelin, in patients with type 2 diabetes
Περίληψη:
Background: Accumulating data support the atheroprotective role of the novel adipokines, apelin and ghrelin. The aim of the present randomized study was to investigate the effects of aerobic exercise training on these adipokines in patients with type 2 diabetes mellitus (T2DM). Material/Methods: Fifty-four overweight (BMI >25 kg/m2) patients with T2DM, but without vascular complications, were randomized to either the aerobic exercise training group (EG, N=27), 4 times/week, 45-60 min/session; or to the control group (CG, N=27), orally instructed to increase physical activity. Clinical glycemic and lipid parameters, exercise capacity (VO2peak), insulin, HOMA-IR, and serum levels of apelin and ghrelin were assessed at baseline and after 12 weeks. Results: Aerobic exercise significantly improved lipid and glycemic profile and insulin sensitivity compared to CG (p<0.05). Furthermore, between-groups comparison showed a considerable exerciseinduced upregulation in apelin (p=0.007) and VO2peak (p<0.001) levels. Negligible changes in body-weight, waist-hip ratio and ghrelin concentrations were detected within and between groups after the completion of the study (p>0.05). However, subgroup analysis revealed a considerable increment in ghrelin levels only in the exercise-treated women compared to their control counterparts (p=0.038). LDL and HOMA-IR reduction were found to be independent predictors of apelin increment in multiple regression analysis (R2=0.391, p=0.011). Conclusions: In patients with T2DM, systemic, long-term, aerobic exercise exerts positive effects on apelin and ghrelin (only in women), even in the absence of significant weight loss, suggesting its pleiotropic effects. © Med Sci Monit, 2012.
Συγγραφείς:
Kadoglou, N.P.E.
Vrabas, I.S.
Kapelouzou, A.
Lampropoulos, S.
Sailer, N.
Kostakis, A.
Liapis, C.D.
Angelopoulou, N.
Λέξεις-κλειδιά:
adipocytokine; apelin; dipeptidyl peptidase IV inhibitor; ghrelin; glucose; insulin; lipid; metformin; sulfonylurea, aerobic exercise; article; body weight; controlled study; cycling; female; glucose blood level; hormone blood level; human; insulin blood level; insulin sensitivity; kinesiotherapy; lipid blood level; major clinical study; male; non insulin dependent diabetes mellitus; obesity; physical activity; protein blood level; randomized controlled trial; running; sex difference; treadmill exercise; waist hip ratio; walking
