Τίτλος:
Impact of magnetic resonance imaging on cardiac mortality in thalassemia major
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To evaluate whether the introduction of magnetic resonance imaging (MRI) in the management of thalassemia major (TM) patients has affected the risk of cardiac death. Materials and Methods: In all, 804 TM patients from two large reference units were included and the risk of dying of cardiac causes, before and after their first MRI, was assessed by a Cox proportional hazards model with time-dependent covariates. Results: Adding information from MRI reduced the risk of cardiac death from 6.0 deaths/1000 patient-years to 3.9 deaths/1000 patient-years (P = 0.22). The risk of cardiac death before having an MRI study was 82% higher compared to the risk observed after the first MRI. Conclusion: MRI has become a vital component of ongoing management and seems to have a beneficial effect on cardiac mortality in TM. © 2011 Wiley-Liss, Inc.
Συγγραφείς:
Chouliaras, G.
Berdoukas, V.
Ladis, V.
Kattamis, A.
Chatziliami, A.
Fragodimitri, C.
Karabatsos, F.
Youssef, J.
Karagiorga-Lagana, M.
Περιοδικό:
Journal of Magnetic Resonance Imaging
Λέξεις-κλειδιά:
adult; article; cardiovascular magnetic resonance; cardiovascular risk; chelation therapy; clinical decision making; controlled study; female; heart death; human; major clinical study; male; mortality; priority journal; risk assessment; survival; thalassemia major, Adult; beta-Thalassemia; Blood Transfusion; Chelating Agents; Death; Heart; Humans; Iron; Iron Overload; Magnetic Resonance Imaging; Myocardium; Proportional Hazards Models; Regression Analysis; Risk; Treatment Outcome
