Περίληψη:
Aim: The creation of a physician-administered questionnaire to screen patients with Systemic Lupus Erythematosus (SLE) for the presence of symptoms suggestive of neuropsychiatric involvement (NPSLE). Methods: The development of the questionnaire followed three phases. First, a list of manifestations was prepared based on the ACR case definitions for NPSLE. A first questionnaire was constructed including 119 items. To reduce their number, a Delphi analysis was carried out and a second questionnaire with 62 questions was developed. This questionnaire was administered to 139 patients with SLE (58 with NPSLE: 29 active, 29 inactive; and 81 without NPSLE: 39 active, 42 inactive). Questions relevant to the screening of patients were selected on the basis of the receiver operating characteristic (ROC) curve analysis. Results: Twenty-seven questions concerning central nervous system and psychiatric manifestations were found to be relevant; the remaining could be eliminated without significantly affecting AUC. The area under the ROC curve (AUC) was 0.69 (95% CI 0.61-0.78). A score above 17 was considered as suggestive of the presence of NPSLE with a sensitivity of 92.9% (95% CI 85.1-97.3 %) and specificity of 25.4% (95% CI 14.7-39.00 %). Conclusions: This questionnaire could represent a 'core set' of questions that could help in clinical practice to identify patients with neuropsychiatric symptoms requiring further evaluation. © The Author(s), 2011.
Συγγραφείς:
Mosca, M.
Govoni, M.
Tomietto, P.
Aringer, M.
Boumpas, D.
Cervera, R.
Conti, F.
D'Cruz, D.
Doria, A.
De La Fuente, D.
Galeazzi, M.
Houssiau, F.
Huizinga, T.
Khamashta, M.A.
Ines, L.
Duarte, C.
Couto, M.
Meroni, P.
Montecucco, C.
Norkuviene, E.
Riemekasten, G.
Rios, V.
Schneider, M.
Shoenfeld, Y.
Steup-Beekman, G.M.
Szmyrka-Kaczmarek, M.
Tani, C.
Tincani, A.
Tzioufas, A.G.
Voll, R.
Bencivelli, W.
Salaffi, F.
Bombardieri, S.
Λέξεις-κλειδιά:
area under the curve; article; clinical practice; Delphi study; human; major clinical study; mental disease; neurologic disease; patient identification; physician; priority journal; questionnaire; receiver operating characteristic; scoring system; screening test; sensitivity and specificity; symptomatology; systemic lupus erythematosus, Area Under Curve; Delphi Technique; Humans; Lupus Vasculitis, Central Nervous System; Questionnaires; ROC Curve
