Τίτλος:
Deferasirox administration for the treatment of non-transfusional iron overload in patients with thalassaemia intermedia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Abnormal iron regulation in patients with thalassaemia intermedia may lead to iron overload even in the absence of transfusions. There are limited data on iron chelator use in patients with thalassaemia intermedia and no guidelines exist for the management of iron overload. We present data from 11 patients with thalassaemia intermedia treated with deferasirox (Exjade®, 10-20 mg/kg/d) for 24 months. Liver iron concentration and serum ferritin levels significantly decreased over the first 12 months (P = 0·005) and continued to decrease over the remainder of the study (P = 0·005). This small-scale study indicated that deferasirox may be suitable for controlling iron levels in patients with thalassaemia intermedia. © 2010 Blackwell Publishing Ltd.
Συγγραφείς:
Ladis, V.
Berdousi, H.
Gotsis, E.
Kattamis, A.
Περιοδικό:
British Journal of Haematology
Λέξεις-κλειδιά:
deferasirox; esomeprazole; ferritin; iron, adult; article; clinical article; diarrhea; dizziness; drug dose escalation; drug dose increase; drug dose reduction; drug efficacy; drug safety; drug withdrawal; female; ferritin blood level; gastrointestinal disease; gastrointestinal symptom; human; iron overload; malaise; male; priority journal; thalassemia; treatment response, Adult; Benzoic Acids; beta-Thalassemia; Female; Ferritins; Humans; Iron; Iron Chelating Agents; Iron Overload; Liver; Magnetic Resonance Imaging; Male; Treatment Outcome; Triazoles; Young Adult
DOI:
10.1111/j.1365-2141.2010.08346.x
