Τίτλος:
High levels of serum angiogenic growth factors in patients with AL amyloidosis: Comparisons with normal individuals and multiple myeloma patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Summary Serum levels of five angiogenic cytokines were evaluated in 82 patients with primary systemic amyloidosis (AL). Angiopoietin-1, vascular endothelial growth factor, basic fibroblast growth factor and angiogenin were higher in AL patients than in controls (n = 35) and newly-diagnosed, symptomatic, myeloma patients (n = 35). Angiopoetin-1/Angiopoetin-2 ratio was lower in AL compared to controls but higher than in myeloma patients. Angiopoetin-2 correlated with cardiac dysfunction indices; however, none of the angiogenic growth factors was prognostically significant. The increased angiogenic cytokine levels observed in AL seem to represent either a toxic effect of amyloid fibrils or light chains, or a compensatory response to organ dysfunction. © 2010 Blackwell Publishing Ltd.
Συγγραφείς:
Kastritis, E.
Roussou, M.
Michael, M.
Gavriatopoulou, M.
Michalis, E.
Migkou, M.
Delimpasi, S.
Kyrtsonis, M.C.
Gogos, D.
Liapis, K.
Charitaki, E.
Repousis, P.
Terpos, E.
Dimopoulos, M.A.
Περιοδικό:
British Journal of Haematology
Λέξεις-κλειδιά:
amyloid; angiogenin; angiopoietin 1; angiopoietin 2; basic fibroblast growth factor; bortezomib; cytokine; lenalidomide; vasculotropin; angiogenic protein; angiogenin; angiopoietin 1; biological marker; fibroblast growth factor 2; pancreatic ribonuclease; tumor protein; vasculotropin A; VEGFA protein, human, adult; aged; amyloidosis; article; controlled study; cytokine production; heart disease; heart index; human; light chain; major clinical study; multiple myeloma; priority journal; prognosis; amyloidosis; blood; comparative study; middle aged; multiple myeloma; very elderly, Adult; Aged; Aged, 80 and over; Amyloidosis; Angiogenic Proteins; Angiopoietin-1; Biological Markers; Fibroblast Growth Factor 2; Humans; Middle Aged; Multiple Myeloma; Neoplasm Proteins; Ribonuclease, Pancreatic; Vascular Endothelial Growth Factor A, Adult; Aged; Aged, 80 and over; Amyloidosis; Angiogenic Proteins; Angiopoietin-1; Biological Markers; Fibroblast Growth Factor 2; Humans; Middle Aged; Multiple Myeloma; Neoplasm Proteins; Ribonuclease, Pancreatic; Vascular Endothelial Growth Factor A
DOI:
10.1111/j.1365-2141.2010.08288.x
