Τίτλος:
Abrupt and durable remission of Henoch-Schönlein purpura nephritis with cyclosporine A
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Henoch-Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in patients with severe HSP-GN, but none have shown convincing favourable effects. We report a case of biopsy-proven HSP-related GN in a 4-year-old girl that responded remarkably well to cyclosporine A (CsA), following failure to respond to other immunosuppressive agents. At 8 months post-CsA treatment, repeat renal biopsy findings were consistent with histological improvement. We conclude that CsA treatment not only exerts beneficial effects on resistant HSP-related GN but may also arrest progression of the disease. © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Συγγραφείς:
Georgaki-Angelaki, E.
Kostaridou, S.
Lourida, A.
Petraki, C.
Lagona, E.
Λέξεις-κλειδιά:
azathioprine; cyclophosphamide; cyclosporin A; methylprednisolone; prednisolone, add on therapy; anaphylactoid purpura; article; case report; disease association; drug blood level; drug dose reduction; drug withdrawal; female; follow up; glomerulonephritis; histopathology; hospital admission; human; human tissue; kidney biopsy; laboratory test; preschool child; priority journal; remission; treatment duration; treatment failure; treatment outcome; treatment response; urinalysis
DOI:
10.1093/ndtplus/sfn105
