Τίτλος:
Increased plasma homocysteine levels in patients with multiple sclerosis and depression
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The aim of the study was to assess the plasma levels of homocysteine in patients with multiple sclerosis (MS) and to investigate whether an association with depression exists. Methods: Plasma homocysteine (Hcy), vitamin B12 and plasma folate were measured in 65 moderately disabled patients with relapsing/remitting MS (RR-MS) and 60 healthy controls. All subjects were assessed with the Beck Depression Inventory (BDI). Results: Hcy levels were significantly increased in MS patients compared to controls (13.5 ± 4.7 μmol/l vs 8.5 ± 3.1, p < 0.001). A significant correlation was found between Hcy levels and BDI scores (Pearson r = 0.3025, p < 0.05). Plasma Hcy was not related to Extended Disability Status Scale (EDSS) score, age, disease duration or vitamin B12 and folate. Conclusion: Moderately disabled MS patients with elevated Hcy levels are particularly prone to develop depressive symptomatology. Further study is warranted in order to elucidate the prognostic and therapeutic implications of this novel finding. © 2008 Triantafyllou et al; licensee BioMed Central Ltd.
Συγγραφείς:
Triantafyllou, N.
Evangelopoulos, M.-E.
Kimiskidis, V.K.
Kararizou, E.
Boufidou, F.
Fountoulakis, K.N.
Siamouli, M.
Nikolaou, C.
Sfagos, C.
Vlaikidis, N.
Vassilopoulos, D.
Περιοδικό:
Annals of General Psychiatry
Λέξεις-κλειδιά:
cyanocobalamin; folic acid; homocysteine, adult; age; amino acid blood level; article; Beck Depression Inventory; controlled study; depression; disease association; disease duration; Extended Disability Status Scale; female; folic acid blood level; high risk patient; human; major clinical study; male; multiple sclerosis; scoring system; symptomatology; vitamin blood level
DOI:
10.1186/1744-859X-7-17
