Τίτλος:
Outbreak caused by a multidrug-resistant Klebsiella pneumoniae clone carrying blaVIM-12 in a university hospital
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
From November 2006 to April 2007, nine nonrepetitive isolates of Klebsiella pneumoniae with reduced susceptibility or resistance to carbapenems were recovered from clinical specimens from separate patients hospitalized in a tertiary care hospital. The imipenem-EDTA synergy test was positive for all isolates. PCR, sequencing, and transferability experiments revealed the novel balVIM-12 metallo-β-lactamase gene, which was plasmid mediated and located in a class 1 integron. Pulsed-field gel electrophoresis demonstrated a single macrorestriction pattern, indicating the clonal spread of VIM-12-producing K. pneumoniae. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Συγγραφείς:
Tokatlidou, D.
Tsivitanidou, M.
Pournaras, S.
Ikonomidis, A.
Tsakris, A.
Sofianou, D.
Περιοδικό:
Journal of Clinical Microbiology
Λέξεις-κλειδιά:
amikacin; amoxicillin plus clavulanic acid; ampicillin; aztreonam; carbapenem; cefepime; cefotaxime; cefoxitin; ceftazidime; ciprofloxacin; clindamycin; cotrimoxazole; edetic acid; ertapenem; imipenem; meropenem; metallo beta lactamase; metronidazole; norfloxacin; piperacillin plus tazobactam; sultamicillin; tetracycline; tigecycline; timentin, adult; aged; antibiotic resistance; antibiotic sensitivity; article; bacterial gene; blaVim 12 gene; controlled study; disk diffusion; Enterobacter infection; female; gene sequence; human; integron; Klebsiella pneumoniae; male; minimum inhibitory concentration; molecular cloning; nonhuman; polymerase chain reaction; priority journal; pulsed field gel electrophoresis; tertiary health care; university hospital, Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Conjugation, Genetic; Disease Outbreaks; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Female; Greece; Hospitals, University; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Polymerase Chain Reaction, Klebsiella pneumoniae
DOI:
10.1128/JCM.01573-07
