Τίτλος:
The impact of the hormonal milieu and stress-associated hypothalamic dopaminergic activation on the rapid compensatory adrenal growth in cycling female rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
OBJECTIVE: We sought to investigate the impact of emotional and surgical stress applied in two hormonally different estrous-cycle phases as well as the hypothalamic dopaminergic involvement on the rapid compensatory adrenal growth (CAG) and the individual adrenal growth (IAG) in rats. DESIGN: After surgery for left and sham adrenalectomy (Adx) carried out on either diestrus-2 (DE-2) or proestrus (PE), CAG and IAG were evaluated in PE or estrus (E), respectively. Hypothalamic dopaminergic activity was also assessed by measuring dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in DE-2, PE and E in controls and in PE and E in sham and left adrenalectomized rats. All groups experienced similar chronic emotional stress assessed by the emotional reactivity score recorded during vaginal screening. RESULTS: In controls, DOPAC levels in DE-2 were higher than in PE and E. In PE, following surgery in DE-2, DOPAC levels and DOPAC/DA ratio were increased compared to PE controls; CAG was not significant, while negative correlations of IAG and CAG with DOPAC/DA ratio were observed. In E, CAG and IAG were significant, while dopaminergic activity was not increased compared to E controls. CONCLUSIONS: The significant CAG and IAG following left Adx in PE but not in DE-2 suggest a pronounced positive impact of the hormonal milieu on this process. The profound attenuation of CAG and IAG in PE suggests a negative effect of stress-associated dopaminergic activation.
Συγγραφείς:
Sfikakis, A.
Pitychoutis, P.M.
Antoniou, K.
Bikas, N.
Papadopoulou-Daifoti, Z.
Περιοδικό:
Vitamins and Hormones
Εκδότης:
Hellenic Endocrine Society
Λέξεις-κλειδιά:
3,4 dihydroxyphenylacetic acid; dopamine; 3,4 dihydroxyphenylacetic acid; dopamine; hormone, adrenal gland; adrenalectomy; animal experiment; animal tissue; article; chronic stress; controlled study; correlation analysis; diestrus; dopamine blood level; dopaminergic activity; emotion; emotional stress; estrus cycle; female; hypothalamus; nonhuman; organ weight; proestrus; rat; sham procedure; surgical stress; adrenalectomy; animal; animal disease; blood; drug effect; estrus cycle; growth, development and aging; mental stress; metabolism; nerve cell; pathophysiology; physiology; time; Wistar rat, 3,4-Dihydroxyphenylacetic Acid; Adrenal Glands; Adrenalectomy; Animals; Dopamine; Estrous Cycle; Female; Hormones; Hypothalamus; Neurons; Rats; Rats, Wistar; Stress, Psychological; Time Factors
DOI:
10.14310/horm.2002.1211
