Περίληψη:
Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. © 2007 European Society for Medical Oncology.
Συγγραφείς:
Vineis, P.
Veglia, F.
Garte, S.
Malaveille, C.
Matullo, G.
Dunning, A.
Peluso, M.
Airoldi, L.
Overvad, K.
Raaschou-Nielsen, O.
Clavel-Chapelon, F.
Linseisen, J.P.
Kaaks, R.
Boeing, H.
Trichopoulou, A.
Palli, D.
Crosignani, P.
Tumino, R.
Panico, S.
Bueno-De-Mesquita, H.B.
Peeters, P.H.
Lund, E.
Gonzalez, C.A.
Martinez, C.
Dorronsoro, M.
Barricarte, A.
Navarro, C.
Quiros, J.R.
Berglund, G.
Jarvholm, B.
Day, N.E.
Key, T.J.
Saracci, R.
Riboli, E.
Autrup, H.
Λέξεις-κλειδιά:
5,10 methylenetetrahydrofolate reductase (FADH2); cytochrome P450 1A1; cytochrome P450 1B1; glutathione transferase M1; manganese superoxide dismutase; reduced nicotinamide adenine dinucleotide phosphate dehydrogenase; tobacco smoke, adult; aged; air pollution; allele; article; bladder cancer; cancer risk; case control study; cohort analysis; confidence interval; controlled study; environmental factor; female; gene deletion; gene interaction; genetic association; genetic susceptibility; genetic variability; heterozygote; homozygote; human; lung cancer; major clinical study; male; metabolism; myeloid leukemia; onset age; oxidative stress; priority journal; risk assessment; single nucleotide polymorphism; smoking; smoking habit; statistical significance
