Τίτλος:
Merkel cell cancer of the skin
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the
elderly with rapidly growing skin nodules found predominantly on
sun-exposed areas of the body. The vast majority of patients present
with localized disease, while up to 30% have regional lymph node
metastases. Despite local excision and the incidence of local
recurrence, regional lymph node metastases and distant metastases is
high and usually occurs within 2 years of primary diagnosis. The optimal
treatment for patients with MCC remains unclear. The best outcome is
achieved with multidisciplinary management including surgical excision
of primary tumor with adequate margins and post-operative radiotherapy
(RT) to control local and regional disease. Patients with regional nodal
metastases should be treated with lymph node dissection plus RT.
Adjuvant chemotherapy (CT) should be considered as part of the initial
management. In case of metastatic disease CT based on regimens used for
small-cell lung cancer is the standard treatment of care.
Συγγραφείς:
Pectasides, D.
Pectasides, M.
Economopoulos, T.
Περιοδικό:
Annals of Oncology
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
chemotherapy; Merkel cell carcinoma; prognosis; radiotherapy; surgery
DOI:
10.1093/annonc/mdl050
