Περίληψη:
Several lines of evidence indicate a causal role of the cytokine
interleukin (IL)-6 in the development of type 2 diabetes in humans. Two
common polymorphisms in the promoter of the IL-6 encoding gene IL6,
-174G > C (rs1800795) and -573G > C (rs1800796), have been investigated
for association with type 2 diabetes in numerous studies but with
results that have been largely equivocal. To clarify the relationship
between the two IL6 variants and type 2 diabetes, we analyzed individual
data on > 20,000 participants from 21 published and unpublished studies.
Collected data represent eight different countries, making this the
largest association analysis for type 2 diabetes reported to date. The
GC and CC genotypes of IL6 -174G > C were associated with a decreased
risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a
risk modification of nearly 9%. No evidence for association was found
between IL6 -573G > C and type 2 diabetes. The observed association of
the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides
further evidence for the hypothesis that immune mediators are causally
related to type 2 diabetes; however, because the association is
borderline significant, additional data are still needed to confirm this
finding.
Συγγραφείς:
Huth, Cornelia
Heid, Iris M.
Vollmert, Caren
Gieger,
Christian
Grallert, Harald
Wolford, Johanna K.
Langer,
Birgit
Thorand, Barbara
Klopp, Norman
Hamid, Yasmin H. and
Pedersen, Oluf
Hansen, Torben
Lyssenko, Valeriya
Groop, Leif
and Meisinger, Christa
Doring, Angela
Lowel, Hannelore
Lieb,
Wolfgang
Hengstenberg, Christian
Rathmann, Wolfgang
Martin,
Stephan
Stephens, Jeffrey W.
Ireland, Helen
Mather, Hugh and
Miller, George J.
Stringham, Heather M.
Boehnke, Michael and
Tuomilehto, Jaakko
Boeing, Heiner
Mohlig, Matthias
Spranger,
Joachim
Pfeiffer, Andreas
Wernstedt, Ingrid
Niklason, Anders
and Lopez-Bermejo, Abel
Fernandez-Real, Jose-Manuel
Hanson,
Robert L.
Gallart, Luis
Vendrell, Joan
Tsiavou, Anastasia
and Hatziagelaki, Erifili
Humphries, Steve E.
Wichmann, H.
-Erich
Herder, Christian
Illig, Thomas
