Τίτλος:
Association between serum tumor necrosis factor-alpha and
corticotropin-releasing hormone levels in women with preterm labor
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim: To evaluate the association of serum corticotropin-releasing
hormone (CRH) and tumor necrosis factor-alpha (TNF-alpha) in preterm
labor.
Methods: Forty-nine primigravidas with a singleton viable pregnancy
between 28 and 34 weeks of gestation were studied. They were divided
into two groups. Group A consisted of 30 pregnant women (mean
gestational age: 30.6 week) who presented with preterm labor and group B
consisted of 19 pregnant women (mean gestational age: 29.8 week) with
normal pregnancies.
Results: Women of group A had significantly higher serum CRH levels
compared to those of group B (P < 0.01). Similarly, serum TNF-alpha
levels were significantly higher in women of group A when compared to
women of group B (7.8 +/- 3.72 pg/mL and 5.1 +/- 3.72 pg/mL,
respectively). Furthermore, a positive correlation was found between
serum CRH and TNF-alpha levels in both groups, which was stronger in
women of group A.
Conclusions: Our findings suggest that the increased levels of TNF-alpha
and CRH found in pregnant women presenting with preterm labor may be
involved in the pathophysiological mechanism of the latter. Furthermore,
a positive interaction may exist between TNF-alpha and placental CRH,
which may lead to enhanced production of the second and, therefore,
facilitate the onset of labor.
Συγγραφείς:
Vitoratos, Nicolaos
Papadias, Konstantinos
Makrakis, Evangelos
and Christodoulakos, George
Panoulis, Konstantinos
Creatsas,
George
Περιοδικό:
Journal of Obstetrics and Gynaecology Research
Εκδότης:
Blackwell Publishing Inc.
Λέξεις-κλειδιά:
corticotrophin-releasing hormone; labor; pregnancy; preterm labor; tumor
necrosis factor-alpha
DOI:
10.1111/j.1447-0756.2006.00441.x
