Περίληψη:
Beta-thalassaemia is a congenital haemolytic anaemia characterized by
partial (intermedia, TI) or complete (major, TM) deficiency in the
production of beta-globin chains. The primary aim of this study was to
determine the prevalence of thromboembolic events in patients with
beta-thalassaemia. To achieve this,a multiplechoice questionnaire was
sent to 56 tertiary referral centres in eight countries (Lebanon, Italy,
Israel, Greece, Egypt, Jordan, Saudi Arabia and Iran), requesting
specific information on patients who had experienced a thromboembolic
event. The study demonstrated that thromboembolic events occurred in a
clinically relevant proportion (1.65%) of 8,860 thalassaemia patients
(TI-24.7% or TM-75.3%) from the Mediterranean and Iran.
Thromboembolism occurred 4.38 times more frequently in TI than TM (p <
0.001),with more venous events occurring in TI and more arterial events
occurring in TM. Thrombosis in thalassaemia was also more common in
females, splenectomized patients and those with profound anaemia
(haemoglobin < 9 g/dl). Due to the increased risk of thromboembolic
events, the rationale for splenectomy should perhaps be re-assessed and
the role of transfusion therapy for the prophylaxis of thrombosis, among
other complications, be evaluated prospectively.
Συγγραφείς:
Taher, Ali
Isma'eel, Hussain
Mehio, Ghassan
Bignamini,
Daniela
Kattamis, Antonis
Rachmilewitz, EliezerA. and
Cappellini, Maria Domenica
