Τίτλος:
Inflammatory markers and in-hospital mortality in acute ischaemic stroke
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: There is substantial evidence that cerebral ischaemia
triggers an inflammatory response. We examined the short-term prognostic
value on mortality of C-reactive protein (CRP), interleukin-6 (IL-6) and
serum amyloid A (SAA) in patients with ischaemic stroke.
Methods: We recruited 203 consecutive patients, under the age of 66
years (mean age = 54.2 +/- 8.1 years, men = 132) who admitted to the
Neurology Department with the diagnosis of non-haemorrhagic stroke.
Patients in atrial fibrillation or with evidence of inflammatory or
malignant disease were excluded. The diagnosis was confirmed with a
computed tomography or magnetic resonance imaging of the brain within 24
h of admission. CRP, IL-6 and SAA levels were determined within 12 h
from admission.
Results: Fourteen (6.9%) patients died during hospitalization. Serum
concentrations of CRP, IL-6 and SAA were significantly higher inpatients
who died compared with those who survived and were independently
associated with early death, after adjusting for various confounding
factors. For one unit increase in IL-6, CRP and SAA there was an 18%,
14% and 9% higher risk of dying during hospitalization, respectively.
Comparisons of the areas under the ROC curve showed that IL-6 had the
best predictive ability. Age-adjusted cut-off point analysis showed that
IL-6 levels > 13 pg/ml were the optimal point that discriminated those
who died from the rest of the patients (sensitivity = 85% and
specificity = 93%).
Conclusions: We demonstrated that in-hospital mortality in ischaemic
stroke is associated with an exacerbation of inflammatory response as it
is reflected by the higher serum levels of IL-6, CRP and SAA. From the
inflammatory markers high IL-6 levels had the strongest independent
predictive value for in-hospital mortality. (c) 2005 Elsevier Ireland
Ltd. All rights reserved.
Συγγραφείς:
Rallidis, Loukianos S.
Vikelis, Michalis
Panagiotakos,
Demosthenes B.
Rizos, Ioannis
Zolindaki, Maria G.
Kaliva,
Karerina
Kremastinos, Dimitrios T.
Περιοδικό:
Atherosclerosis
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
inflammatory markers; in-hospital mortality; interleukin-6; ischaemic
stroke
DOI:
10.1016/j.atherosclerosis.2005.11.032
