Περίληψη:
Corticotropin-releasing hormone (CRH), CRH-related peptides, and CRH
receptors play major roles in coordinating the behavioral, endocrine,
autonomic, and immune responses to stress. The wide influence of the CRH
system on physiological processes in both brain and periphery implicates
the respective peptides in the pathophysiology of numerous disorders
characterized by dysregulated stress responses. The potential use of CRH
antagonists is presently under intense investigation. Selective
antagonists have been used experimentally to elucidate the role of
CRH-related peptides in disease processes, such as anxiety and
depression, sleep disorders, addictive behavior, inflammatory disorders,
acute and chronic neurodegeneration, and preterm labor.
Συγγραφείς:
Zoumakis, E.
Grammatopoulos, D. K.
Chrousos, G. P.
