Περίληψη:
Objective: To examine the relationship between body mass index (BMI) and
waist-hip ratio (WHR) with serum levels of insulin-like growth factor-I
(IGF-I), and its binding protein (IGFBP)-3.
Design: Cross-sectional study on 2139 women participating in a
case-control study on breast cancer and endogenous hormones. Data on
lifestyle and reproductive factors were collected by means of
questionnaires. Body height, weight, waist and hip circumferences were
measured. Serum levels of IGF-I and insulin-like binding protein
(IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted
mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist
circumference, and WHR were calculated by linear regression. Results
were adjusted for potential confounders associated with IGF-I and
IGFBP-3.
Results: Adjusted mean serum IGF-I values were lower in women with BMI <
22.5 kg/m(2) or BMI > 29.2 kg/m(2) compared to women with BMI within
this range (P-heterogeneity < 0.0001, P-trend = 0.35). Insulin-like
growth factor-I was not related to WHR after adjustment for BMI.
IGF-binding protein-3 was linearly positively related to waist and WHR
after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear
relation with BMI and a linear inverse relationship with WHR (P-trend =
0.005).
Conclusions: Our data confirm the nonlinear relationship of circulating
IGF-I to total adiposity in women. Serum IGFBP-3 was positively related
to central adiposity. These suggest that bioavailable IGF-I levels could
be lower in obese compared to non-obese women and inversely related to
central adiposity.
Συγγραφείς:
Gram, I. T.
Norat, T.
Rinaldi, S.
Dossus, L.
Lukanova,
A.
Tehard, B.
Clavel-Chapelon, F.
van Gils, C. H.
van
Noord, P. A. H.
Peeters, P. H. M.
Bueno-de-Mesquita, H. B. and
Nagel, G.
Linseisen, J.
Lahmann, P. H.
Boeing, H.
Palli,
D.
Sacerdote, C.
Panico, S.
Tumino, R.
Sieri, S. and
Dorronsoro, M.
Quiros, J. R.
Navarro, C. A.
Barricarte, A.
and Tormo, M-J
Gonzalez, C. A.
Overvad, K.
Johnsen, S.
Paaske
Olsen, A.
Tjonneland, A.
Travis, R.
Allen, N. and
Bingham, S.
Khaw, K-T
Stattin, P.
Trichopoulou, A. and
Kalapothaki, V.
Psaltopoulou, T.
Casagrande, C.
Riboli, E.
and Kaaks, R.
