Τίτλος:
Neutrophil CD64 expression and serum IL-8: Sensitive early markers of
severity and outcome in sepsis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the present study was to investigate which biomarker/s
reliably assess severity and mortality early in the sepsis process. In
47 critically-ill patients within the 24 h of septic onset, Interleukins
(IL)-8, -1 beta, -6, -10, and -12p70, tumor necrosis factor-alpha
(TNF-alpha), procalcitonin (PCT) and C-reactive protein (CRP) were
measured in serum. Additionally, CD64 expression was measured in
neutrophils. In early sepsis, neutrophil CD64 expression and IL-8 levels
are the only biomarkers that increased with sepsis severity,
differentiating disease stages: sepsis, severe sepsis and septic shock
(p < 0.001). The biomarkers that best evaluate the severity of sepsis
(via APACHE II) were CD64, IL-8 and IL-6 (p < 0.01), and the severity of
organ failure (via SOFA) were CD64 and IL-8 (p < 0.01). CD64 expression
and IL-8 levels were associated with mortality within 28-days (OR = 1.3,
p = 0.01 for CD64 and OR = 1.26, p = 0.024 for IL-8 by logistic
regression analysis) and ROC curve analysis showed high sensitivity and
specificity for predicting sepsis stages and the 28 day mortality. We
conclude that there is an early increase of neutrophil CD64 expression
and IL-8 levels during sepsis. Based on this single measurement it is
possible to reliably assess the stage, detect the severity and predict
the 28-day mortality of sepsis. (c) 2007 Elsevier Ltd. All rights
reserved.
Συγγραφείς:
Livaditi, Olga
Kotanidou, Anastasia
Psarra, Aikaterini and
Dimopoulou, Ioanna
Sotiropoulou, Christina
Augustatou, Kallirroi
and Papasteriades, Chryssa
Armaganidis, Apostolos
Roussos,
Charis
Orfanos, Stylianos E.
Douzinas, Emmanuel E.
Εκδότης:
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
cytokines; Fc-gamma receptors; neutrophils; early sepsis; flow cytometry
DOI:
10.1016/j.cyto.2007.02.007
