Περίληψη:
Aim. To investigate the effect of the mode of labour and delivery on the
total antioxidant status (TAS), and the biomarker of DNA oxidation,
8-hydroxy-deoxyguanosine (8-OHdG) serum levels, in mothers and their
newborns. Subjects and methods. Some 106 women with normal pregnancy and
normal blood biochemical parameters were divided into 4 groups: Group A
( n = 28) with normal labour and vaginal delivery ( VG), Group B ( n =
25) with scheduled cesarean section ( CS), Group C ( n = 26) with
‘emergency’ CS, and Group D ( n = 27) with prolonged labour + VG. Blood
was obtained fr? m the mothers at the beginning of labour, and
immediately after delivery ( pre- and post-delivery), as well as from
the umbilical cord ( CB). TAS, 8-OHdG and creatine kinase (CK) were
measured in the sera with appropriate methodology. Results. TAS levels
were almost similar in all the groups pre- delivery, and in CB
irrespective of the mode of labour and delivery, and remarkably
decreased in Groups C and D post-delivery. 8-OHdG levels in Group C (
0.94 +/- 0.08 ng/ml) and Group D (0.98 +/- 0.08 ng/ml) were
significantly higher than those in Group A (0.26 +/- 0.01 ng/ml, p <
0.001) and Group B (0.28 +/- 0.07 ng/ml, p < 0.001) post-delivery.
8-OHdG levels were low in CB, independent of the mode of labour. CK
positively correlated with 8-OHdG ( r = 0.48, p < 0.001), the latter
negatively correlated with TAS ( r = - 0.53, p < 0.01). Conclusions. The
lowest TAS and the highest 8-OHdG levels were found in Groups C and D
post-delivery, probably due to the long-term participation of the
mothers’ skeletal and uterus muscles, whereas 8-OHdG levels were low in
CB irrespective of the mode of delivery, possibly as a consequence of
the antioxidant action of the placenta and/or the low lipid levels in
the serum of the umbilical cord.
Συγγραφείς:
Schulpis, Kleopatra H.
Lazaropoulou, Christina
Vlachos, George
D.
Partsinevelos, George A.
Michalakakou, Kelly
Gavrili,
Stavroula
Gounaris, Antonia
Antsaklis, Aris
Papassotiriou,
Ioannis
