Τίτλος:
Photodynamic therapy of murine non-melanoma skin carcinomas with diode
laser after topical application of aluminum phthalocyanine chloride
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this work is to study pharmacokinetics and photodynamic
efficiency of aluminium phthalocyanine chloride (AICIPc) in
dimethylsulfoxide/Tween 80/water solution, after topical application on
hairless mice bearing non-melanoma skin carcinomas. The concentration of
photosensitizer in normal skin and tumor biopsies 1-6 hours after
application was assessed by fluorescence spectroscopy of chemical
extractions. The concentration of photosensitizer was 40 times higher in
tumor than in normal skin even 1 h after application.
For photodynamic therapy (PDT) AlClPc was excited by a diode laser
emitting at 670 nm, 1 h after application. Seven different combinations
of therapeutic parameters were chosen. The efficiency was assessed as
the percentage of complete tumor remission, the tumor growth retardation
and the cosmetic outcomes. The highest complete remission 60% was
achieved with the combination of 75 mW/cm(2) with 150 J/cm(2). No
recurrence rate was observed in any treatment parameters group and the
cosmetic outcome in all completely treated tumors was excellent. The
results show that the effectiveness of PDT is highly dependent on
fluence rate. In addition, they are promising for further investigation
of this PDT scheme in preclinical studies mainly in non-melanoma skin
carcinomas up to 7mm.
Συγγραφείς:
Kyriazi, Maria
Alexandratou, Eleni
Yova, Dido
Rallis,
Michail
Trebst, Tilmann
Εκδότης:
SPIE - INT SOC OPTICAL ENGINEERING
Τίτλος συνεδρίου:
THERAPEUTIC LASER APPLICATIONS AND LASER-TISSUE INTERACTION III
Λέξεις-κλειδιά:
photodynamic therapy; non melanoma skin carcinomas; topical
administration; aluminum phthalocyanine chloride
