Περίληψη:
EPIC-Heart is the cardiovascular component of the European Prospective
Investigation into Cancer and Nutrition ( EPIC), a multi-centre
prospective cohort study investigating the relationship between
nutrition and major chronic disease outcomes. Its objective is to
advance understanding about the separate and combined influences of
lifestyle ( especially dietary), environmental, metabolic and genetic
factors in the development of cardiovascular diseases by making best
possible use of the unusually informative database and biological
samples in EPIC. Between 1992 and 2000, 519,978 participants ( 366,521
women and 153,457 men, mostly aged 35 - 70 years) in 23 centres in 10
European countries commenced follow-up for causespecific mortality,
cancer incidence and major cardiovascular morbidity. Dietary information
was collected with quantitative questionnaires or semi-quantitative food
frequency questionnaires, including a 24-h dietary recall sub-study to
help calibrate the dietary measurements. Information was collected on
physical activity, tobacco smoking, alcohol consumption, occupational
history, socio-economic status, and history of previous illnesses.
Anthropometric measurements and blood pressure recordings were made in
the majority of participants. Blood samples were taken from 385,747
individuals, from which plasma, serum, red cells, and buffy coat
fractions were separated and aliquoted for long-term storage. By 2004,
an estimated 10,000 incident fatal and non-fatal coronary and stroke
events had been recorded. The first cycle of EPIC-Heart analyses will
assess associations of coronary mortality with several prominent dietary
hypotheses and with established cardiovascular risk factors. Subsequent
analyses will extend this approach to non-fatal cardiovascular outcomes
and to further dietary, biochemical and genetic factors.
Συγγραφείς:
Danesh, John
Saracci, Rodolfo
Berglund, Goran
Feskens, Edith
and Overvad, Kim
Panico, Salvatore
Thompson, Simon
Fournier,
Agnes
Clavel-Chapelon, Francoise
Canonico, Marianne
Kaaks,
Rudolf
Linseisen, Jakob
Boeing, Heiner
Pischon, Tobias and
Weikert, Cornelia
Olsen, Anja
Tjonneland, Anne
Johnsen,
Soren Paaske
Jensen, Majken Karoline
Quiros, Jose R. and
Gonzalez Svatetz, Carlos Alberto
Sanchez Perez, Maria-Jose and
Larranaga, Nerea
Navarro Sanchez, Carmen
Moreno Iribas,
Concepcion
Bingham, Sheila
Khaw, Kay-Tee
Wareham, Nick and
Key, Timothy
Roddam, Andrew
Trichopoulou, Antonia
Benetou,
Vassiliki
Trichopoulos, Dimitrios
Masala, Giovanna
Sieri,
Sabina
Tumino, Rosario
Sacerdote, Carlotta
Mattiello, Amalia
and Verschuren, W. M. Monique
Bueno-de-Mesquita, H. Bas
Grobbee,
Diederick E.
van der Schouw, Yvonne T.
Melander, Olle and
Hallmans, Goran
Wennberg, Patrik
Lund, Eiliv
Kumle, Merethe
and Skeie, Guri
Ferrari, Pietro
Slimani, Nadia
Norat, Teresa
and Riboli, Elio
