Τίτλος:
Vascular endothelial growth factor levels in post-CABG pleural effusions
are associated with pleural inflammation and permeability
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Vascular endothelial growth factor (VEGF) participates in
the pathogenesis of exudative pleural effusions (PEs). In the present
study, we determined the pleural fluid (PF) and serum VEGF levels in
patients with post-coronary artery by-pass grafting (post-CABG) PEs.
Methods: Thirty-eight patients with post-CABG (two with bilateral) PEs
were studied. PEs were divided into “early” (occurring earlier than
30 days after surgery) and “late” ones. VEGF levels were measured
using ELISA.
Results: (i) Serum and PF VEGF levels did not differ significantly when
all the patients (P = 0.053) or those with late effusions (P = 0.6) were
analyzed; serum VEGF levels were significantly elevated in comparison to
PF VEGF levels in patients with early (P = 0.007) effusions. (ii) Serum
VEGF levels were significantly higher in patients with early than in
those with late effusions (P = 0.033), while PF VEGF levels were not
significantly different between the two groups (P = 0.77). (iii) PF VEGF
levels were higher than corresponding serum levels in 4/24 patients with
early and in 10/16 patients with late post-CABG PEs (P = 0.006). (iv) In
PEs VEGF levels significantly correlated with red blood cells (P =
0.015), nucleated cells (P = 0.003), protein levels (P = 0.002) and
lactate dehydrogenase (LDH) levels (P = 0.04).
Conclusion: In post-CABG PEs, preferential local production of VEGF in
the pleural cavity is most commonly observed a month or later after
surgery. The fact that in PEs VEGF levels correlate with markers of
pleural inflammation (inflammatory cells and LDH levels) and vascular
hyperpermeability (protein levels) suggests that VEGF may be involved in
the pathogenesis of post-CABG PEs. (c) 2006 Elsevier Ltd. All rights
reserved.
Συγγραφείς:
Kalomenidis, Ioannis
Stathopoulos, Georgios T.
Barnette, Randal
and Papiris, Spyros
Blackwell, Timothy S.
Roussos, Charis and
Light, Richard W.
Περιοδικό:
Advances in Respiratory Medicine
Εκδότης:
W B SAUNDERS CO LTD
Λέξεις-κλειδιά:
post-coronary artery by-pass grafting; pleural inflammation; pleural
effusion; vascular endothelial growth factor
DOI:
10.1016/j.rmed.2006.05.018
