Περίληψη:
Introduction Soy products are of particular interest because of their
potential health benefits in a range of hormonal conditions, such as
osteoporosis, due to their high content in phytoestrogens. Because
equol, the main metabolite from soy isoflavones, is thought to be
powerful, the present study was designated to evaluate the bone-sparing
effects of equol by either providing the molecule through the diet or by
eliciting its endogenous production by modulating intestinal microflora
by short-chain fructooligosaccharides (sc-FOS) or live microbial
(Lactobacillus casei) together with daidzein, its precursor.
Methods A comparison with daidzein and genistein was also performed.
Rats (3 months old) were ovariectomised (OVX) or sham-operated (SH).
Ovariectomised rats were randomly assigned to six experimental diets for
3 months: a control diet (OVX), the control diet supplemented with
either genistein (G), or daidzein (D), or equol (E) at the level of 10
mu g/g body weight/d. The remaining OVX rats were given daidzein at the
dose of 10 mu g/g body weight/d, simultaneously with short-chain FOS
(Actilight (R), Beghin-Meiji) (D+FOS) or Lactobacillus casei (Actimel,
Danone) (D+L). The SH rats were given the same control diet as OVX.
Results Genistein, daidzein or equol exhibited a bone sparing effect.
Indeed, total femoral bone mineral density (BMD) was significantly
enhanced (compared to that of OVX rats), as was the metaphyseal
compartment. Bone strength was improved by E consumption, but not by
genistein or daidzein given alone. As far as the FOS diet is concerned,
the addition of prebiotics significantly raised efficiency of the
daidzein protective effect on both femoral BMD and mechanical
properties. The effects of lactobacillus were similar, except that the
increase in metaphyseal-BMD was not significant.
Conclusion In conclusion, long-term equol consumption, like genistein
and daidzein, in the ovariectomized rat, provides bone sparing effects.
Adding indigestible sugars, such as FOS or live microbial as L. casei,
in the diet significantly improves daidzein protective effects on the
skeleton.
Συγγραφείς:
Mathey, J.
Mardon, J.
Fokialakis, N.
Puel, C. and
Kati-Coulibaly, S.
Mitakou, S.
Bennetau-Pelissero, C. and
Lamothe, V.
Davicco, M. J.
Lebecque, P.
Horcajada, M. N. and
Coxam, V.
