Τίτλος:
Correlation of folate, vitamin B-12 and homocysteine plasma levels with
depression in an elderly Greek population
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Alterations in folate, vitamin B-12 and homocysteine plasma
levels have been associated with aging, neuronal development and
depressive symptomatology. Nevertheless, the associations are not strong
enough to suggest the use of these parameters in every day practice for
diagnostic or therapeutic purposes.
Objectives: The aim of the study was to investigate the relationship
between plasma folate, vitamin B-12 and homocysteine in depressive
states in the elderly.
Methods: Community-dwelling, elderly individuals over 60 years of age
were screened with the Geriatric Depression Scale. The study population
was divided into two groups: (a) 33 subjects with depression and (b) 33
healthy controls. All participants were clinically evaluated and
completed a questionnaire for socio-demographic and clinical data.
Measurements of folate, vitamin B-12 and homocysteine were estimated in
all blood samples and results were statistically evaluated at p < 0.05
level of significance.
Results: No statistical significance emerged for the socio-demographic
data between the two groups. Chronic diseases such as stroke,
hypercholesterolemia, hypertension and diabetes also did not differ
between the depression and control group. Group (a) had significantly
lower levels of folate and vitamin B-12 than group (b). Homocysteine was
significantly higher in depressed individuals than in controls.
Conclusion: Lower levels of plasma folate and/or vitamin B-12, and
higher levels of plasma homocysteine are associated with depression in
elderly individuals. (c) 2007 The Canadian Society of Clinical Chemists.
Published by Elsevier Inc. All rights reserved.
Συγγραφείς:
Dimopoulos, Nikolaos
Piperi, Christina
Salonicioti, Anistea and
Psarra, Vassiliki
Gazi, Flerri
Papadimitriou, Alexandros and
Lea, Robert W.
Kalofoutis, Anastasios
Περιοδικό:
Clinical Biochemistry
Εκδότης:
PERGAMON-ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
folate; vitamin B-12; homocysteine; depression; elderly
DOI:
10.1016/j.clinbiochem.2007.01.007
