Περίληψη:
Ischemia-reperfusion injury significantly contributes to abdominal
aortic aneurysm (AAA)related mortality and morbidity; therefore, we
measured oxidative stress during open AAA repair and investigated any
potential associations with intraoperative or perioperative events
(aortic clamping time, blood loss, and the need to transfer to the
intensive care unit). Blood samples were collected at specific time
points from 53 patients undergoing open AAA repair: (1) before induction
of anesthesia; (2) 15, 30, 60, and 120 minutes after aortic clamping;
(3) 15 and 60 minutes after clamp removal; and (4) 24 hours
postoperatively. Malondialdehyde (MDA) levels were measured by a
spectrophotometric method. Baseline MDA values in patients with AAA were
significantly higher than in controls (P < .0001). A positive
correlation was found between preoperative MDA levels and the size of
AAAs (Pearson correlation = 0.578, P < .001). No difference was observed
in MDA levels between ruptured and nonruptured AAAs; however, when all
symptomatic patients (ruptured and elective symptomatic AAAs, n = 18)
were considered, there was a significant elevation in MDA levels (P <
.001). There was also a significant increase in MDA values in patients
transferred postoperatively to the intensive care unit (P < .001).
Finally, a positive association was found between the duration of aortic
clamping with MDA values at 15 and 60 minutes after declamping, but not
after 24 hours (Pearson correlation = 0.467, P < .001). MDA levels may
predict the postoperative course of elective and ruptured AAAs.
Συγγραφείς:
Papalambros, Efstathios
Sigala, Fragiska
Georgopoulos, Sotiris
and Paraskevas, Kosmas I.
Andreadou, Ioanna
Menenakos,
Xaralambos
Sigalas, Panagiotis
Papalambros, Alexandros L. and
Vourliotakis, Georgios
Giannopoulos, Athanasios
Bakoyiannis,
Christos
Bastounis, Elias
