Τίτλος:
Elevated morning serum interleukin (IL)-6 or evening salivary cortisol
concentrations predict posttraumatic stress disorder in children and
adolescents six months after a motor vehicle accident
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: This study examined prospectively the activity of the
hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and
inflammatory factors in children shortly after a motor vehicle accident
(MVA) in relation to later posttraumatic stress disorder (PTSD)
development.
Patients and methods: Fifty six children, aged 7-18, were studied after
an MVA and 1 and 6 months later; 40 subjects served as controls. Morning
serum cortisol and interleukin (IL)-6 and plasma catecholamine
concentrations were measured within 24h after the event. Salivary
cortisol was measured 5 times at defined time points during the same
day. PTSD diagnoses 1 and 6 months later were based on K-SADS interview.
Results: Morning serum IL-6 concentrations, measured within the first
24h after the accident, were higher in children that developed PTSD 6
months later than those who did not and those of the control group.
Longitudinal IL-6 measurements revealed normalization of IL-6 in the
PTSD group, white no differences between the three groups were detected
1 and 6 months later. Evening salivary cortisol and morning serum IL-6
after the accident were positively inter-related (r = 0.54, p<0.001) and
in separate regression analyses both predicted PTSD development 6 months
later. In contrast, morning serum IL-6 did nor correlate with morning
serum or salivary cortisol concentrations.
Conclusions: Immediate posttraurnatic alterations in neuroendocrine or
inflammatory factors-increased evening salivary cortisol and/or
increased morning serum IL-6 concentrations-are involved in subsequent
PTSD development in children and adolescents. (C) 2007 Elsevier Ltd. All
rights reserved.
Συγγραφείς:
Pervanidou, Panagiota
Kolaitis, Gerasimos
Charitaki, Stella and
Margeli, Alexandra
Ferentinos, Spyros
Bakoula, Chrysa and
Lazaropoulou, Christina
Papassotiriou, Ioannis
Tsiantis, John
and Chrousos, George P.
Περιοδικό:
Psychoneuroendocrinology
Εκδότης:
PERGAMON-ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
children; PTSD; salivary cortisol; serum IL-6; motor vehicle accidents;
prediction; stress
DOI:
10.1016/j.psyneuen.2007.07.001
