Τίτλος:
Thyroid dysfunction associated with increased low-density lipoprotein
cholesterol in epileptic children treated with carbamazepine
monotherapy: A causal relationship?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Lipid abnormalities and thyroid dysfunction have been
reported in patients treated with antiepileptic drugs. The aim of this
study was to evaluate prospectively the association between thyroid and
lipid profile in children treated with carbamazepine (CBZ) monotherapy.
Materials and methods: Thyroid function was evaluated in 18 epileptic
children, previously reported with CBZ-induced changes in serum lipid
profile, before and at 6, 12 and 24 months of CBZ monotherapy.
Results: All children had normal thyroid function before the initiation
of CBZ treatment. During CBZ therapy thyroid dysfunction, with increased
thyrotropin (TSH) and decreased thyroxine (T4), free thyroxine (FT4) and
triiodothyronine (T3) was found, while, significant association was
revealed between serum low-density lipoprotein cholesterol (LDL-C) and
TSH levels at 6 (r = 0.469; p = 0.043) and 12 (r = 0.730; p = 0.001)
months of treatment.
Conclusion: Lipid abnormalities may be associated with thyroid hormone
disturbance in children treated with CBZ monotherapy. Since thyroid
dysfunction and hypercholesterolemia are both associated with a higher
atherosclerotic risk special attention and further studies are needed in
epileptic patients treated with CBZ monotherapy. (C.) 2007 European
Paediatric Neurology Society Published by Elsevier Ltd. All rights
reserved.
Συγγραφείς:
Attilakos, Achilleas
Garoufi, Anastasia
Voudris, Konstantinos
and Mastroyianni, Sotiria
Fotinou, Aspasia
Papadimitriou,
Dimitrios T.
Gavalakis, Nikolaos
Prassouli, Alexia
Katsarou,
Eustathia
Περιοδικό:
European Journal of Paediatric Neurology
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
thyroid; carbamazepine monotherapy; children; epilepsy; low-density
lipoprotein cholesterol
DOI:
10.1016/j.ejpn.2007.03.002
