Περίληψη:
Numerous models and biomarkers have been proposed to estimate prognosis and improve decision-making in patients with acute heart failure (AHF). The present literature review provides a critical appraisal of externally validated prognostic models in AHF, combining clinical data and biomarkers. We perform a literature review of clinical studies, using the following terms: “acute heart failure,” “acute decompensated heart failure,” “prognostic models,” “risk scores,” “mortality,” “death,” “hospitalization,” “admission,” and “biomarkers.” We searched MEDLINE and EMBASE databases from 1990 to 2020 for studies documenting prognostic models in AHF. External validation of each prognostic model to another AHF cohort, containing at least one biomarker, was prerequisites for study selection. Among 358 initially screened studies, 9 of them fulfilled all searching criteria. The majority of prognostic models were simplified, including a narrow number of variables (up to 10), with good performance regarding calibration and discrimination (c-statistics > 0.65). Unfortunately, the derived and validated cohorts showed a wide variety in patients’ characteristics (e.g., cause of AHF and therapy). Moreover, the prognostic models used various time-points and a plethora of combinations of variables determining different cut-off values. Although the application of valid prognostic models in AHF population is quite promising, a precise methodological approach should be set for the derivation and validation of prognostic models in AHF with unified characteristics to establish an effective performance in clinical practice. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Kadoglou, N.P.E.
Parissis, J.
Karavidas, A.
Kanonidis, I.
Trivella, M.
Λέξεις-κλειδιά:
amino terminal pro brain natriuretic peptide; biological marker; creatinine; nitrogen; potassium; sodium; troponin; urea, acute coronary syndrome; acute heart failure; all cause mortality; cardiovascular mortality; clinical practice; diastolic blood pressure; heart failure with preserved ejection fraction; heart failure with reduced ejection fraction; heart left ventricle ejection fraction; hospital mortality; hospital readmission; human; potassium blood level; prognosis; protein blood level; Review; sodium blood level; systolic blood pressure; urea nitrogen blood level
