Τίτλος:
Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this study is to investigate the preventive role of 3 herbal formulation products on reducing the incidence of radiation-induced dermatitis in patients undergoing radiotherapy for either breast or head and neck cancer. A total of 59 patients participated in the study. The novel herbal products, a combination of beeswax, olive oil, Calendula and Hypericum oils and Aloe gel, were daily and regularly being used by the patients during radiotherapy and 2 weeks after treatment end. Acute skin toxicity was scored weekly during radiotherapy and after treatment for a further 4-week follow-up period. Demographic data were analyzed by descriptive statistics. Statistical analyses of the study objectives were based on an intent-to-treat principle. Most of the patients presented with grade I (RTOG/EORTC) toxicity in the first weeks of radiotherapy, progressed to grade II but reverted to grade I toxicity up until the study end. A total of 94.9% of the patients had Dermatology Life Quality Index up to 1, and 66.1% remained in this scale. The application of the novel natural product combinations proved to be statistically significantly effective in reducing the intensity of radiation dermatitis, positively affecting the quality of life of the patients. © The Author(s) 2020.
Συγγραφείς:
Koukourakis, G.
Pissakas, G.
Ganos, C.G.
Sivolapenko, G.
Kardamakis, D.
Περιοδικό:
International Journal of Lower Extremity Wounds
Εκδότης:
SAGE Publications Inc.
Λέξεις-κλειδιά:
Aloe vera extract; beeswax; olive oil, adult; aged; Aloe vera; Article; breast cancer; Calendula officinalis; controlled study; Dermatology Life Quality Index; drug efficacy; drug safety; drug tolerability; female; follow up; head and neck cancer; human; human tissue; Hypericum perforatum; hypothyroidism; major clinical study; male; olive tree; prevalence; prospective study; quality of life; questionnaire; radiation dermatitis; Aloe; head and neck tumor; radiation dermatitis, Aloe; Head and Neck Neoplasms; Humans; Quality of Life; Radiodermatitis
DOI:
10.1177/1534734620923912
