Τίτλος:
Morphometric analysis of fibrovascular pigment epithelial detachments treated with ranibizumab and aflibercept
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To assess fibrovascular pigment epithelial detachments (PED) and their response to two different anti-VEGF agents using optical coherence tomography (OCT) morphometric analysis. Methods: Seventy-three consecutive, treatment-naïve eyes with fibrovascular PED (>125 μm) treated with ranibizumab or aflibercept were retrospectively included. A custom-made software was used to manually segment and calculate PED maximum height, base area, volume and internal reflectivity at baseline, after three injections and 1 year. Results: Visual acuity (VA) change was 2 ETDRS letters ± 7.6 after three injections and 3.2 ETDRS letters ± 10.3 at 1 year. There was no significant difference between VA changes amongst the two drugs. At 1 year, anti-VEGF treatment resulted in a mean reduction of 125 μm in maximum PED height, of 2.26 mm2 in base area and of 0.54 mm3 in volume with a corresponding increase in reflectivity. These changes were more prominent in the aflilbercept group. The observed PED and VA changes at year 1 were strongly correlated with their values at baseline and after three injections. Conclusions: Anti-VEGF treatment resulted in a reduction of all PED dimensions and a corresponding increase in optical reflectivity. Higher, larger and more hypo-reflective PEDs demonstrated a better anatomical response, especially with aflibercept, but this was not correlated with VA. © The Author(s) 2021.
Συγγραφείς:
Karampelas, M.
Syriga, M.
Petrou, P.
Georgalas, I.
Papaconstantinou, D.
Brouzas, D.
Περιοδικό:
European Journal of Ophthalmology
Εκδότης:
SAGE Publications Ltd
Λέξεις-κλειδιά:
aflibercept; ranibizumab; aflibercept; angiogenesis inhibitor; fusion protein; ranibizumab; vasculotropin receptor, age related macular degeneration; aged; Article; B scan; Bruch membrane; cohort analysis; controlled study; female; fluorescence angiography; human; image analysis; image segmentation; indocyanine green angiography; major clinical study; male; morphometry; ophthalmoscopy; optical coherence tomography; retina detachment; retinal pigment epithelium; retrospective study; spectral domain optical coherence tomography; very elderly; visual acuity; intravitreal drug administration; retinal pigment epithelium, Angiogenesis Inhibitors; Humans; Intravitreal Injections; Ranibizumab; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Retinal Pigment Epithelium; Retrospective Studies; Tomography, Optical Coherence
DOI:
10.1177/11206721211005706
