Τίτλος:
Successful treatment of coexistent acne fulminans and severe hidradenitis suppurativa with adalimumab
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The coexistence of hidradenitis suppurativa (HS) and acne fulminans (AF) has only recently been reported in the literature. We present a case of a 17-year-old man who presented with a 2 years history of severe acne and HS. He was initially started on oral clindamycin and rifampicin for 3 months with no clinical improvement. Acne lesions became worse with the presence of nodules and necrotic ulcers, while weight loss, low-grade fever, back and knee pain, and psychological distress were noted. We prescribed adalimumab in its standard dosing regimen. Remission of AF was achieved in 3 months, whereas adalimumab has not been as effective in treating the HS lesions. Its dosage was increased to 80 mg weekly and more than 80% clinical improvement of HS lesions was obtained in 2 months. The patient maintained on this dosage till this day and efficacy is sustained. TNF-α inhibitors are considered an effective option in the treatment of HS, while it has been also suggested as a treatment option in AF. Our patient was successfully treated with adalimumab. Since the coexistence of HS and AF has a devastating emotional effect on the patient, there is an urgent need to implement therapeutic approaches. © 2021 S. Karger AG, Basel. All rights reserved.
Συγγραφείς:
Kontochristopoulos, G.
Agiasofitou, E.
Platsidaki, E.
Kapsiocha, A.
Gregoriou, S.
Rigopoulos, D.
Περιοδικό:
Skin Appendage Disorders
Λέξεις-κλειδιά:
adalimumab; antibiotic agent; clindamycin; rifampicin, acne; acne fulminans; adolescent; anxiety disorder; Article; backache; body weight loss; case report; clinical article; depression; distress syndrome; drug dose increase; drug efficacy; fever; follow up; human; knee pain; male; nuclear magnetic resonance imaging; remission; scar formation; suppurative hidradenitis
