Τίτλος:
Serum vitamin D levels in patients with obstructive sleep apnea syndrome and level changes after continuous positive airway pressure therapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: Patients with obstructive sleep apnea syndrome (OSAS) have been found to exhibit lower serum vitamin D levels, even when the control groups are matched for confounding conditions. However, contradictory studies are also present. This study aimed to compare serum 25-hydroxyvitamin D (25(OH)D) levels between adult patients with OSAS and non-apneic controls and to evaluate the changes in 25(OH)D levels after 3 and 12 months of continuous positive airway pressure (CPAP) therapy. Methods: The study was comprised of 30 patients with OSAS and 30 controls. Serum 25(OH)D levels were determined at baseline and after 3 and 12 months of CPAP therapy in all patients with OSAS. For analysis, patients with OSAS were divided into subgroups by adherence, with adherence defined as CPAP usage for > 4 h per night on at least 70% of nights. Results: The 25(OH)D levels were not significantly different between OSAS and control groups at baseline. 25(OH)D levels did not change after 3 and 12 months of CPAP therapy. Patients who were CPAP-adherent showed less reduction in 25(OH)D levels compared with non-adherent ones (21.18 ± 9.3 vs. 12.13 ± 3.8 ng/mL, p = 0.022) after 1 year. The 25(OH)D levels were significantly correlated with higher daily CPAP usage at 3 and 12 months. Mean daily CPAP usage was a significant predictor of serum 25(OH)D levels at 12 months. Conclusions: Patients with OSAS who demonstrated good CPAP adherence showed significantly higher 25(OH)D levels after 1 year compared with those not adequately using CPAP. Long-term good CPAP adherence and highly daily CPAP usage positively affected 25(OH)D levels in patients with OSAS. © 2020, Springer Nature Switzerland AG.
Συγγραφείς:
Siachpazidou, D.I.
Kotsiou, O.S.
Stavrou, V.
Pastaka, C.
Gogou, E.
Kechagia, M.
Varsamas, C.
Economou, N.-T.
Zouridis, S.
Patrikioy, E.
Seitanidis, G.
Pinaka, M.
Sistou, A.
Hatzoglou, C.
Gourgoulianis, K.I.
Περιοδικό:
Sleep and Breathing
Εκδότης:
Springer Science and Business Media Deutschland GmbH
Λέξεις-κλειδιά:
25 hydroxyvitamin D; alkaline phosphatase; calcium; glucose; hemoglobin A1c; oxygen; vitamin D binding protein; 25-hydroxyvitamin D; vitamin D, adult; apnea; arterial oxygen saturation; Article; asthma; atrial fibrillation; body mass; chronic disease; clinical article; comorbidity; comparative study; continuous positive airway pressure; controlled study; coronary artery disease; depression; dyslipidemia; electroencephalogram; Epworth sleepiness scale; female; follow up; gastroesophageal reflux; glucose blood level; heart arrhythmia; human; hyperglycemia; hypertension; male; medical history; metabolic syndrome X; neurologic disease; obesity; oxygen blood level; oxygen desaturation index; patient compliance; polysomnography; respiratory airflow; rhinitis; sleep disordered breathing; sleep parameters; sleep quality; sleep time; smoking; snoring; somnolence; thyroid disease; thyroid function test; valvular heart disease; vitamin blood level; vitamin D deficiency; vitamin supplementation; blood; case control study; middle aged; positive end expiratory pressure ventilation; sleep disordered breathing, Case-Control Studies; Continuous Positive Airway Pressure; Female; Humans; Male; Middle Aged; Patient Compliance; Sleep Apnea, Obstructive; Vitamin D
DOI:
10.1007/s11325-020-02146-6
