Ερευνητικό υλικό ΕΚΠΑ

Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

Αγγλικά

Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 ± 1.24 vs 7.90 ± 0.94 m/s; adjusted P < 0.01 and <0.05). In the view of previous evidence linking plasma GGT concentration to the level of systemic oxidative stress, our findings suggest a role of oxidative stress in subclinical arterial damage and in prehypertension, even in healthy subjects free of cardiometabolic risk. Arterial organ damage may represent the link between GGT and hypertension. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.

2021

Kozakova, M.
Gastaldelli, A.
Morizzo, C.
Højlund, K.
Nilssson, P.M.
Ferrannini, E.
Heine, R.J.
Dekker, J.
de Rooij, S.
Nijpels, G.
Boorsma, W.
Kok, A.
Mitrakou, A.
Tournis, S.
Kyriakopoulou, K.
Thomakos, P.
Lalic, N.
Lalic, K.
Jotic, A.
Lukic, L.
Civcic, M.
Nolan, J.
Yeow, T.P.
Murphy, M.
DeLong, C.
Neary, G.
Colgan, M.P.
Hatunic, M.
Gaffney, P.
Boran, G.
Konrad, T.
Böhles, H.
Fuellert, S.
Baer, F.
Zuchhold, H.
Golay, A.
Bobbioni, E.H.
Barthassat, V.
Makoundou, V.
Lehmann, T.N.O.
Merminod, T.
Petrie (now Dundee), J.R.
Perry, C.
Neary, F.
MacDougall, C.
Shields, K.
Malcolm, L.
Laakso, M.
Salmenniemi, U.
Aura, A.
Raisanen, R.
Ruotsalainen, U.
Sistonen, T.
Laitinen, M.
Saloranta, H.
Coppack, S.W.
McIntosh, N.
Ross, J.
Pettersson, L.
Khadobaksh, P.
Balkau, B.
Mhamdi, L.
Guillanneuf, M.T.
Laville, M.
Bonnet, F.
Brac de la Perriere, A.
Louche-Pelissier, C.
Maitrepierre, C.
Peyrat, J.
Beltran, S.
Serusclat, A.
Gabriel, R.
Sánchez, E.M.
Carraro, R.
Friera, A.
Novella, B.
Nilssone, P.
Persson, M.
Östling, G.
Melander, O.
Burri, P.
Piatti, P.M.
Monti, L.D.
Setola, E.
Galluccio, E.
Minicucci, F.
Colleluori, A.
Walker, M.
Ibrahim, I.M.
Jayapaul, M.
Carman, D.
Ryan, C.
Short, K.
McGrady, Y.
Richardson, D.
Patel, S.
Beck-Nielsen, H.
Staehr, P.
Hojlundd, K.
Vestergaard, V.
Olsen, C.
Hansen, L.
Bolli, G.B.
Porcellati, F.
Fanelli, C.
Lucidi, P.
Calcinaro, F.
Saturni, A.
Ferranninia, E.
Natali, A.
Muscelli, E.
Pinnola, S.
Kozakovaa, M.
Hills, S.A.
Landucci, L.
Mota, L.
Gastaldelli, A.
Ciociaro, D.
Mari, A.
Pacini, G.
Cavaggion, C.
Mingrone, G.
Guidone, C.
Favuzzi, A.
Di Rocco, P.
Anderwald, C.
Bischof, M.
Promintzer, M.
Krebs, M.
Mandl, M.
Hofer, A.
Luger, A.
Waldhäusl, W.
Roden, M.
Palombo, C.
RISC Investigators

Journal of Human Hypertension

Springer Nature BV

35

4

334-342

adiponectin; C reactive protein; gamma glutamyltransferase; glutamic acid; insulin; serine; gamma glutamyltransferase, adult; age; alcohol consumption; arterial remodeling; arterial stiffness; artery disease; Article; blood pressure; blood vessel parameters; cardiometabolic risk; carotid diameter; carotid intima-media thickness; carotid-femoral pulse wave velocity; female; gamma glutamyl transferase blood level; human; human experiment; insulin blood level; insulin sensitivity; lifestyle; low risk population; luminal diameter; male; middle aged; normal human; oxidative stress; prehypertension; sex difference; arterial wall thickness; hypertension; prehypertension; risk factor, Blood Pressure; Carotid Intima-Media Thickness; gamma-Glutamyltransferase; Humans; Hypertension; Prehypertension; Risk Factors

https://doi.org/10.1038/s41371-020-0337-1

10.1038/s41371-020-0337-1

https://pergamos.lib.uoa.gr/uoa/dl/object/3119919