Τίτλος:
Ganglion cell layer thickening in patients suffering from Obstructive Sleep Apnea–Hypopnea syndrome with long Mean Apnea–Hypopnea Duration during sleep
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To study the effects of mean apnea–hypopnea duration (MAD), a useful indicator of blood oxygenation, on peripapillary retinal nerve fiber layer (RNFL), macular ganglion cell to inner plexiform layer (GC-IPL) and macular retinal thickness in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). Methods: Sixty-five patients recently diagnosed with OSAHS and 35 healthy individuals were enrolled in this cross-sectional study. OSAHS patients were divided according to their MAD values into group 1 with 16 participants (MAD:10–15.5 s), group 2 with 17 participants (MAD:15.5-19 s), group 3 with 17 participants (MAD:19-30 s) and group 4 with 15 participants (MAD > 30 s). The average and sectorial values of RNFL, GC-IPL and retinal thickness were measured by SS-OCT (DRI OCT Triton, Topcon). Intraocular pressure was recorded by Goldmann Applanation and Pascal Dynamic Contour Tonometer (DCT-IOP). Results: The average RNFL and retinal thickness values were higher in group 4, but did not reach statistical significance. With the exception of the central 1 mm at the fovea, GC-IPL was always thickened in group 4, and significant differences were evident when its average value was compared with group 2 (p = 0.03), its superior and inferior-nasal values were compared with group 2 (p = 0.02, p = 0.006, respectively) and group 3 (p = 0.01, p = 0.02, respectively), its superior-temporal value was compared with group 3 (p = 0.003) and the control group (p = 0.03), and its superior-nasal value was compared with group 2 (p = 0.03), group 3 (p = 0.001) and the control group (p = 0.03). DCT-IOP was significantly positively correlated with the duration of sleep in which oxygen saturation (SaO2) was decreased under 90% (r = 0.359, p = 0.01). Conclusion: We report a novel observation of GC-IPL thickening in OSAHS patients experiencing long MAD, a parameter which incorporates the severity of breathing events during sleep. Higher DCT-IOP was noted with advancing hypoxemia. © 2020, Springer Nature B.V.
Συγγραφείς:
Chalkiadaki, E.
Andreanos, K.
Karmiris, E.
Florou, C.
Tsiafaki, X.
Amfilochiou, A.
Georgalas, I.
Koutsandrea, C.
Papaconstantinou, D.
Περιοδικό:
International Ophthalmology
Εκδότης:
Springer Science and Business Media B.V.
Λέξεις-κλειδιά:
adult; Article; comparative study; controlled study; cross-sectional study; disease severity; female; human; intraocular pressure; major clinical study; male; mean apnea hypopnea duration; middle aged; ocular pulse amplitude; optical coherence tomography; oxygen saturation; polysomnography; respiratory tract parameters; retinal ganglion cell layer; retinal inner plexiform layer; retinal nerve fiber layer; retinal thickness; sleep; sleep disordered breathing; sleep time; swept source optical coherence tomography; visual system parameters; nerve fiber; retina ganglion cell; sleep; sleep disordered breathing, Cross-Sectional Studies; Humans; Nerve Fibers; Retinal Ganglion Cells; Sleep; Sleep Apnea, Obstructive; Tomography, Optical Coherence
DOI:
10.1007/s10792-020-01648-2
