Τίτλος:
Isolated Intraductal Carcinoma of the Prostate in Prostatectomy Specimens: Report of 2 Cases and Review of the Literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Intraductal carcinoma of the prostate (IDCp) is a distinct neoplastic entity, and although recognized for some time, it was included for the first time in the histologic classification of prostate cancer in the 2016 publication of World Health Organization. IDCp represents an intraductal or intra-acinar proliferation of malignant cells, with preservation of the basal cell layer. Even though IDCp is usually accompanied by a high-grade invasive component, low-grade invasive carcinoma can rarely be seen adjacent to the lesion. Even rarer is the incidence of isolated IDCp in needle biopsies, while a few such cases have been reported in prostatectomy specimens. We report 2 cases with isolated IDCp without any invasive component. A review of the literature is performed including the diagnostic challenges of IDCp and its morphologic mimics, immunohistochemical markers, molecular aspects, and prognostic implications. Even though it is not yet clear whether IDCp represents an intraductal spread of invasive cancer or a precursor of invasive carcinoma, the existence of isolated IDCp reinforces the idea that, at least in some of the cases, IDCp is a precancerous lesion. Further molecular studies need to be performed in order to clarify its pathogenesis. © The Author(s) 2020.
Συγγραφείς:
Grypari, I.M.
Logotheti, S.
Lazaris, A.C.
Kallidonis, P.
Fokaefs, E.
Melachrinou, M.
Zolota, V.
Tzelepi, V.
Περιοδικό:
International Journal of Surgical Pathology
Εκδότης:
SAGE Publications Inc.
Λέξεις-κλειδιά:
prostate specific antigen, adult; aged; Article; bladder biopsy; cancer prognosis; case report; clinical article; cystectomy; cystoscopy; Gleason score; histopathology; human; human tissue; immunohistochemistry; lymph node dissection; male; middle aged; muscle invasive bladder cancer; needle biopsy; pelvis lymph node; precancer; priority journal; prostate adenocarcinoma; prostatectomy; transitional cell carcinoma; very elderly
DOI:
10.1177/1066896920920357
