Περίληψη:
The skin is the most common organ of involvement during the course of lupus erythematosus (LE). The literature data concerning the dermatoscopic patterns of the different clinical variants of cutaneous LE (CLE), namely chronic (CCLE), subacute (SCLE), and acute (ACLE), are scarce. To determine the dermatoscopic spectrum of CLE and to correlate the dermatoscopic features with the histological findings. This was a retrospective, observational, multicenter, cohort study. We evaluated the dermatoscopic features in a cohort of patients diagnosed with CLE. Furthermore, we investigated their frequency per clinical subtype and correlated them with the anatomic alterations. We included 79 patients. The most prevalent dermatoscopic features of CCLE included follicular plugs (86.4%, P <.01), patchy distribution (75%, P =.1) of mostly linear curved vessels (56.8%, P =.8), white scales (68.2%, P <.01), and structureless white color (68.2%, P <.01). The most common criteria of SCLE were patchy distribution (90%, P =.1) of mostly linear curved vessels (53.3%, P =.8) and fine white scales (60%, P <.01), while ACLE was characterized by erythema (100%, P <.05) and patchy distribution (100%, P =.1) of mostly dotted vessels (60%, P =.4). Follicular plugs/rosettes in dermatoscopy strongly correlated with follicular plugs in histology (rho = 0.919). Hyperkeratosis significantly correlated with white (rho = 0.644) and yellow/brown scales (rho = 0.225), telangiectasia with linear curved vessels (rho = 0.321) and white color with dermal fibrosis (rho = 0.623). Depending on CLE subtype, distinct dermatoscopic patterns are recognized. In CLE there is a high correlation between certain dermatoscopic criteria and the underneath anatomic alteration. © 2020 Wiley Periodicals LLC.
Συγγραφείς:
Apalla, Z.
Papadimitriou, I.
Iordanidis, D.
Errichetti, E.
Kyrgidis, A.
Rakowska, A.
Sotiriou, E.
Vakirlis, E.
Bakirtzi, A.
Liopyris, K.
Fotiadou, C.
Lazaridou, E.
Lallas, A.
Ioannidis, D.
Λέξεις-κλειδιά:
acute cutaneous lupus erythematosus; adult; Article; chronic cutaneous lupus erythematosus; clinical evaluation; clinical feature; cohort analysis; controlled study; correlation analysis; disease severity; epiluminescence microscopy; erythema; female; Greece; hair follicle; histopathology; human; human tissue; hyperkeratosis; incontinentia pigmenti; Italy; major clinical study; male; middle aged; multicenter study; observational study; Poland; prevalence; retrospective study; rosette formation; skin atrophy; skin blood vessel; skin color; skin defect; skin fibrosis; skin lupus erythematosus; clinical trial; diagnostic imaging; skin; skin lupus erythematosus; systemic lupus erythematosus, Cohort Studies; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Retrospective Studies; Skin
