Τίτλος:
Myocardial Involvement in Rheumatic Disorders
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose of Review: Autoimmune rheumatic diseases (ARDs) affect 8% of the population and approximately 78% of patients are women. Myocardial disease in ARDs is the endpoint of various pathophysiologic mechanisms including atherosclerosis, valvular disease, systemic, myocardial, and/or vascular inflammation, as well as myocardial ischemia and replacement/diffuse fibrosis. Recent Findings: The increased risk of CVD in ARDs leads to excess comorbidity not fully explained by traditional cardiovascular risk factors. It seems that the chronic inflammatory status typically seen in ARDs, promotes both the development of myocardial inflammation/fibrosis and the acceleration of atherosclerosis. Summary: CMR (cardio-vascular magnetic resonance) is the ideal imaging modality for the evaluation of cardiac involvement in patients with ARDs, as it can simultaneously assess cardiac function and characterize myocardial tissues with regard to oedema and fibrosis. Due to its high spatial resolution, CMR is capable of identifying various disease entities such as myocardial oedema /inflammation, subendocardial vasculitis and myocardial fibrosis, that are often missed by other imaging modalities, notably at an early stage of development. Although generally accepted guidelines about the application of CMR in ARDs have not yet been formulated, according to our experience and the available published literature, we recommend CMR in ARD patientS with new-onset heart failure (HF), arrhythmia, for treatment evaluation/change or if there is any mismatch between patient symptoms and routine non-invasive evaluation. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Markousis-Mavrogenis, G.
Pepe, A.
Gargani, L.
Kariki, U.
Bonou, M.
Koutsogeorgopoulou, L.
Manolopoulou, D.
Tektonidou, M.G.
Vartela, V.
Kolovou, G.
Mavrogeni, S.I.
Περιοδικό:
Current Heart Failure Reports
Λέξεις-κλειδιά:
corticosteroid; gadolinium; immunoglobulin; immunoglobulin G; methylprednisolone; triacylglycerol, ankylosing spondylitis; aortic arch syndrome; autoimmune disease; cardiovascular magnetic resonance; cardiovascular risk; contrast-enhanced ultrasound; coronary angiography; coronary artery disease; dermatomyositis; diastolic dysfunction; disease activity; echocardiography; eosinophilic granuloma; heart arrhythmia; heart failure; heart function; heart infarction; heart muscle perfusion; human; hypertension; immunomodulation; inflammation; mucocutaneous lymph node syndrome; myocardial disease; myocarditis; myositis; nuclear magnetic resonance imaging; polyarteritis nodosa; positron emission tomography; prevalence; Review; rheumatic disease; risk factor; single photon emission computed tomography; sudden cardiac death; systolic blood pressure; thorax pain; tissue characterization; volume of distribution; Wegener granulomatosis; cardiac muscle; cardiomyopathy; cine magnetic resonance imaging; complication; pathology; procedures; rheumatic disease, Cardiomyopathies; Echocardiography; Humans; Magnetic Resonance Imaging, Cine; Myocardium; Rheumatic Diseases
DOI:
10.1007/s11897-020-00471-1
