Ερευνητικό υλικό ΕΚΠΑ

Factors associated with sclerostin levels – A calcification inhibitor – In individuals with type 2 diabetes mellitus; Is autonomic neuropathy the missing link?

Αγγλικά

Background: Sclerostin inhibits bone formation and its expression is upregulated in the vasculature during the arterial calcification process as a counterregulatory mechanism preventing further calcification. Lower extremity arterial calcification (LEAC) is common in neuropathic patients with type 2 diabetes (T2DM). Herein, we investigated for associations between plasma sclerostin levels and diabetic neuropathy as well as LEAC in subjects with T2DM. Methods: A total of 74 individuals with and 76 without T2DMwere recruited. Plasma sclerostin levels were measured by ELISA. Diagnosis of cardiac autonomic neuropathy (CAN) was based on the battery of the four autonomic tests, while of somatosensory peripheral neuropathy (DPN) on neuropathy symptom score and neuropathy disability score. LEAC was assessed with conventional ankle and foot x-rays. Results: Plasma sclerostin levels were higher in participants with LEAC vs. those without LEAC in both diabetes and non-diabetes cohorts (p = 0.035 and p = 0.003, respectively). In the diabetes cohort, patients with CAN, but not with DPN, had higher sclerostin levels when compared with those without CAN (p < 0.001). Multivariate analysis in the diabetes cohort demonstrated that sclerostin levels were associated positively with CAN and LEAC, while in the non-diabetes cohort there was a trend for a positive association with male gender and presence of LEAC. Conclusion: Plasma sclerostin levels are increased in individuals with LEAC irrespectively of diabetes status. In addition, plasma sclerostin concentrations are associated independently with LEAC and CAN in people with T2DM. © 2020 Elsevier Inc.

2020

Eleftheriadou, I.
Tentolouris, A.
Anastasiou, I.A.
Mourouzis, I.
Tsilingiris, D.
Kosta, O.
Grigoropoulou, P.
Tentolouris, N.

Journal of Diabetes and its Complications

HANLEY & BELFUS-ELSEVIER INC

34

10

sclerostin; signal transducing adaptor protein; SOST protein, human, aged; ankle radiography; artery calcification; Article; autonomic neuropathy; cardiac autonomic neuropathy; cohort analysis; cross-sectional study; diabetic neuropathy; diabetic patient; enzyme linked immunosorbent assay; female; foot radiography; human; lower limb; major clinical study; male; non insulin dependent diabetes mellitus; peripheral neuropathy; priority journal; X ray; autonomic neuropathy; blood; blood vessel calcification; complication; diabetic neuropathy; middle aged; non insulin dependent diabetes mellitus; peripheral occlusive artery disease; risk factor, Adaptor Proteins, Signal Transducing; Aged; Autonomic Nervous System Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Peripheral Arterial Disease; Risk Factors; Vascular Calcification

https://doi.org/10.1016/j.jdiacomp.2020.107677

10.1016/j.jdiacomp.2020.107677

https://pergamos.lib.uoa.gr/uoa/dl/object/3120671