Τίτλος:
Increased Serum KLF4 in Severe Atheromatosis and Extensive Aneurysmal Disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Krüppel-like factor 4 (KLF4) is known to preserve vascular homeostasis. In the present study, we sought to correlate serum KLF4 levels with arterial aneurysm size and their clinical presentation. We also explored the association between serum KLF4 levels and the severity of extracranial carotid and peripheral arterial disease. Methods: Patients undergoing surgery for various forms of atheromatosis (ATH group) or for arterial aneurysm repair (AA group) were eligible for inclusion. KLF4 levels were measured via enzyme-linked immunosorbent assay. Results: Patients in the atheromatic and aneurysmal groups had significantly higher serum KLF4 levels compared with controls. Patients with permanent end-organ damage (ATH3) had higher serum KLF4 (6.96 ± 0.75 pg/mL) compared with patients with asymptomatic internal carotid stenosis >70% or claudication (ATH1) (2.76 ± 0.68 pg/mL; mean difference [MD], −4.20; 95% confidence interval [95% CI], −5.35 to −3.04; P < 0.01) and those with transient ischemic attack or rest pain (ATH2) (4.47 ± 1.08 pg/mL; MD, −2.48; 95% CI, −3.76 to −1.21). Furthermore, patients with an asymptomatic aneurysm of a diameter 250–300% of that of the normal artery (AA1, 5.01 ± 1.08 pg/mL) had considerably lower serum KLF4 compared with those suffering from either a symptomatic aneurysm or an asymptomatic aneurysm of a diameter >350% of that of normal artery (AA3, 6.63 ± 1.92 pg/mL; MD, −2.61; 95% CI, −5.04 to −0.18; P < 0.01). Conclusions: Serum KLF4 levels are significantly increased in patients with end-organ damage related to atheromatosis as well as those with extensive aneurysmal disease. © 2020 Elsevier Inc.
Συγγραφείς:
Bakoyiannis, C.
Mylonas, K.S.
Papoutsis, K.
Kakavia, K.
Schizas, D.
Iliopoulos, D.
Nikiteas, N.
Liakakos, T.
Kapelouzou, A.
Περιοδικό:
Annals of Vascular Surgery
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
kruppel like factor 4; kruppel like factor; kruppel like factor 4, abdominal aortic aneurysm; aneurysm; aneurysm size; aneurysm surgery; Article; asymptomatic disease; atheromatosis; carotid artery disease; carotid artery obstruction; claudication; clinical article; clinical feature; controlled study; disease severity; enzyme linked immunosorbent assay; human; human tissue; immunohistochemistry; internal carotid artery; internal iliac artery aneurysm; pain; peripheral occlusive artery disease; popliteal artery aneurysm; priority journal; protein blood level; retrospective study; thoracic aorta aneurysm; transient ischemic attack; aneurysm; blood; diagnostic imaging; severity of illness index; upregulation, Aneurysm; Carotid Stenosis; Humans; Kruppel-Like Transcription Factors; Peripheral Arterial Disease; Retrospective Studies; Severity of Illness Index; Up-Regulation
DOI:
10.1016/j.avsg.2020.04.015
