Τίτλος:
Leucine-rich alpha-2 glycoprotein 1, high mobility group box 1, matrix metalloproteinase 3 and annexin A1 as biomarkers of ulcerative colitis endoscopic and histological activity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective The LRG, HMGB1, MMP3 and ANXA1 proteins have been implicated in different inflammatory pathways in ulcerative colitis (UC), but their role as specific biomarkers of both endoscopic and histological activity has yet to be elucidated. In the present study, we aimed to evaluate the LRG1, HMGB1, MMP3 and ANXA1 as potential serum biomarkers for UC endoscopic and histological activity. Methods This cross-sectional study included UC patients under 5-ASA, and healthy controls (HC) undergoing colonoscopy. Blood and biopsy samples were obtained and endoscopic Mayo sub-score (Ms) was recorded for the UC patients. Intramucosal calprotectin as a marker of histologic activity was evaluated in all biopsy samples and serum LRG1, HMGB1, MMP3 and ANXA1 levels were measured in the blood samples. Results The HCs ANXA1 level was lower compared to that of the UC group [P = 0.00, area under the curve (AUC) = 0.881] and so was the HCs MMP3 level compared to that of patients (P = 0.00, AUC = 0.835). The HCs ANXA1 levels were also lower compared to these of the independent Ms groups, even to the Ms = 0 (P = 0.00, AUC = 0.913). UC endoscopic activity was associated with MMP3 levels (r = 0.54, P = 0.000) but not with ANXA1, LRG1 and HMGB1 levels Conclusion Serum ANXA1 is a potential diagnostic biomarker of UC and serum MMP3 is a potential biomarker of UC endoscopic and histological activity. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Συγγραφείς:
Kourkoulis, P.
Michalopoulos, G.
Katifelis, H.
Giannopoulou, I.
Lazaris, A.C.
Papaconstantinou, I.
Karamanolis, G.
Gazouli, M.
Περιοδικό:
European Journal of Gastroenterology and Hepatology
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
5 acetamidosalicylic acid; C reactive protein; calgranulin; glycoprotein; high mobility group B1 protein; human placenta lactogen; interleukin 6; leucine rich alpha 2 glycoprotein 1; lipocortin 1; stromelysin; unclassified drug; biological marker; calgranulin; glycoprotein; high mobility group B1 protein; leucine; lipocortin 1; stromelysin, adult; adverse outcome; Article; clinical article; colon biopsy; colonoscopy; controlled study; cross-sectional study; female; histology; human; immunochemistry; lamina propria; macrophage; male; middle aged; priority journal; protein expression; remission; ulcerative colitis; Youden index; chemistry; colonoscopy; feces; intestine mucosa; severity of illness index; ulcerative colitis, Annexin A1; Biomarkers; Colitis, Ulcerative; Colonoscopy; Cross-Sectional Studies; Feces; Glycoproteins; HMGB1 Protein; Humans; Intestinal Mucosa; Leucine; Leukocyte L1 Antigen Complex; Matrix Metalloproteinase 3; Severity of Illness Index
DOI:
10.1097/MEG.0000000000001783
