Τίτλος:
Prevalence, distribution and clinical significance of joints, muscles and bones in sarcoidosis: an 18F-FDG-PET/CT study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: In Sarcoidosis joints-muscles-bones (JMBs) localizations are of the least common. 18F-FDG-PET/CT imaging revolutionized detection of JMBs involvement by adding metabolic activity information and allowing for a comprehensive, whole-body mapping of the disease. Aim and methods: This study investigated prevalence, distribution, and clinical significance of JMBs sarcoidosis in 195 consecutive patients that underwent 18F-FDG PET/CT examination. Results: Joint and bone involvement were encountered in 15% of patients with a mean of the maximum-standardized-uptake-value (SUVmax) of 6.1. Most common location was the axial skeleton. Hypercalciuria was significantly more frequent in patients with osseous involvement (p = 0.003). Muscle activity (SUVmax = 2.4) was encountered in 20% of the patients, most frequently in treatment-naïve (p = 0.02). The muscles of the lower extremities were affected the most. Muscle and bone localization coexist in 50% of the cases. JMBs disease was almost asymptomatic, not related to chronicity but to pulmonary, nodal, and systemic disease. Long-term follow-up and treatment response of affected patients confirmed sarcoidosis. Conclusion: 18F-FDG-PET/CT revealed JMBs localizations and coexistence with other organ sites supporting the concept that sarcoidosis is a systemic disease. By allowing an integrative interpretation of multi-organ involvement in the context of a pattern highly suggestive of sarcoidosis, it strongly keeps-off the diagnosis of malignancy. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Papiris, S.A.
Manali, E.D.
Papaioannou, A.I.
Georgakopoulos, A.
Kolilekas, L.
Pianou, N.K.
Kallergi, M.
Papaporfyriou, A.
Kallieri, M.
Apollonatou, V.
Papadaki, G.
Malagari, K.
Kelekis, N.L.
Pneumatikos, S.G.
Chatziioannou, S.
Περιοδικό:
Expert Review of Respiratory Medicine
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
fluorodeoxyglucose f 18; fluorodeoxyglucose f 18; radiopharmaceutical agent, adult; Article; asymptomatic disease; bone; chronicity; coughing; diffusing capacity for carbon monoxide; disease activity; dyspnea; fatigue; female; follow up; forced expiratory volume; forced vital capacity; human; human tissue; hypercalciuria; joint; lower limb; major clinical study; male; maximum standardized uptake value; muscle; muscle contraction; osseous sarcoidosis; positron emission tomography-computed tomography; prevalence; retrospective study; systemic disease; total lung capacity; treatment response; bone; diagnostic imaging; joint; middle aged; muscle; pathology; sarcoidosis, Adult; Bone and Bones; Female; Fluorodeoxyglucose F18; Humans; Joints; Male; Middle Aged; Muscles; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Sarcoidosis
DOI:
10.1080/17476348.2020.1775587
