Περίληψη:
We evaluated the association between automatically measured carotid total plaque area (TPA) and the estimated glomerular filtration rate (eGFR), a biomarker of chronic kidney disease (CKD). Automated average carotid intima–media thickness (cIMTave) and TPA measurements in carotid ultrasound (CUS) were performed using AtheroEdge (AtheroPoint). Pearson correlation coefficient (CC) was then computed between the TPA and eGFR for (1) males versus females, (2) diabetic versus nondiabetic patients, and (3) between the left and right carotid artery. Overall, 339 South Asian Indian patients with either type 2 diabetes mellitus (T2DM) or CKD, or hypertension (stage 1 or stage 2) were retrospectively analyzed by acquiring cIMTave and TPA measurements of their left and right common carotid arteries (CCA; total CUS: 678, mean age: 54.2 ± 9.8 years; 75.2% males; 93.5% with T2DM). The CC between TPA and eGFR for different scenarios were (1) for males and females −0.25 (P <.001) and −0.35 (P <.001), respectively; (2) for T2DM and non-T2DM −0.26 (P <.001) and −0.49 (P =.02), respectively, and (3) for left and right CCA −0.25 (P <.001) and −0.23 (P <.001), respectively. Automated TPA is an equally reliable biomarker compared with cIMTave for patients with CKD (with or without T2DM) with subclinical atherosclerosis. © The Author(s) 2020.
Συγγραφείς:
Puvvula, A.
Jamthikar, A.D.
Gupta, D.
Khanna, N.N.
Porcu, M.
Saba, L.
Viskovic, K.
Ajuluchukwu, J.N.A.
Gupta, A.
Mavrogeni, S.
Turk, M.
Laird, J.R.
Pareek, G.
Miner, M.
Sfikakis, P.P.
Protogerou, A.
Kitas, G.D.
Nicolaides, A.
Viswanathan, V.
Suri, J.S.
Λέξεις-κλειδιά:
high density lipoprotein cholesterol; low density lipoprotein cholesterol, adult; area under the curve; arterial wall thickness; Article; B scan; carotid artery; carotid atherosclerosis; chronic kidney failure; cohort analysis; common carotid artery; controlled study; correlation analysis; cross-sectional study; diagnostic test accuracy study; estimated glomerular filtration rate; external carotid artery; female; glucose blood level; high risk patient; human; internal carotid artery; left common carotid artery; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; receiver operating characteristic; retrospective study; right common carotid artery; risk assessment; total plaque area
