Τίτλος:
An economic analysis of preimplantation genetic testing for aneuploidy by polar body biopsy in advanced maternal age
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: What are the cost per live birth and the incremental cost of preventing a miscarriage with preimplantation genetic testing for aneuploidy (PGT-A) by polar body biopsy and array-based comprehensive genome hybridisation (aCGH) versus regular IVF/ICSI without PGT-A for infertility treatment in women 36–40 years of age?. Design: Decision tree model. Population: A randomised clinical trial on PGT-A (ESTEEM study). Methods: Two treatment strategies were compared: one cycle of IVF/ICSI with or without PGT-A. Costs and effects were analysed with this model for four different cost scenarios: high-, higher medium, lower medium and low-cost. Base case, sensitivity, threshold, and probabilistic sensitivity analyses were used to examine the cost-effectiveness implications of PGT-A. Results: PGT-A increased the cost per live birth by approximately 15% in the high-cost scenario to approximately 285% in the low-cost scenario. Threshold analysis revealed that PGT-A would need to be associated with an absolute increase in pregnancy rate by 6% to >39% or, alternatively, would need to be US$2,969 (high-cost scenario) to US$4,888 (low-cost scenario) cheaper. The incremental cost to prevent one miscarriage by PGT-A using the base case assumptions was calculated to be US$34,427 (high-cost scenario) to US$51,146 (low-cost scenario). A probabilistic sensitivity analysis showed cost-effectiveness for PGT-A from 1.9% (high-cost scenario) to 0.0% (low-cost scenario) of calculated samples. Conclusions: While avoiding unnecessary embryo transfers and miscarriages are important goals, patients and doctors need to be aware of the high-cost implications of applying PGT-A using aCGH on polar bodies. Tweetable abstract: PGT-A by polar body biopsy and comprehensive genome hybridisation increases cost per live birth and requires high financial spending per miscarriage averted. © 2020 Royal College of Obstetricians and Gynaecologists
Συγγραφείς:
Neumann, K.
Sermon, K.
Bossuyt, P.
Goossens, V.
Geraedts, J.
Traeger-Synodinos, J.
Parriego, M.
Schmutzler, A.
van der Ven, K.
Rudolph-Rothfeld, W.
Vonthein, R.
Griesinger, G.
Περιοδικό:
BJOG: An International Journal of Obstetrics and Gynaecology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
aneuploidy; Article; biopsy; controlled study; cost effectiveness analysis; decision tree; genetic screening; health care cost; human; hybridization; in vitro fertilization; intracytoplasmic sperm injection; maternal age; polar body; pregnancy rate; priority journal; sensitivity analysis; spontaneous abortion; adult; cost benefit analysis; economics; female; genetic screening; genetics; pregnancy; preimplantation genetic diagnosis; randomized controlled trial; spontaneous abortion; transplantation, Abortion, Spontaneous; Adult; Aneuploidy; Cost-Benefit Analysis; Female; Genetic Testing; Humans; Maternal Age; Polar Bodies; Pregnancy; Preimplantation Diagnosis
DOI:
10.1111/1471-0528.16089
