Τίτλος:
Adolescents and young women with functional hypothalamic amenorrhoea: is it time to move beyond the hormonal profile?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To ascertain the role of deranged eating behaviours (DEBs) in the development of functional hypothalamic amenorrhoea (FHA) and the reciprocal role of psychopathological traits on both disorders. Methods: A prospective case–control study was conducted spanning the period January 2016 to April 2018. Forty-one consecutive FHA females and 86 healthy controls were recruited. We assessed the DEBs and other FHA predisposing factors via self-reported questionnaires. Possible correlations amongst the variables were examined using the Spearman’s correlation coefficient (rho), whilst multivariate logistic regression was carried out to identify independent predictors of DEBs. Results: Mean scores on Eating Attitudes Test-26 (EAT-26) were significantly higher in females with FHA (p < 0.0001). Women with FHA were characterised by significantly higher scores at the sub-scale items of dieting (p = 0.03) and bulimia and food preoccupation (p < 0.001) compared to healthy controls. Significant difference was also observed between the mean scores of the two groups in all other questionnaires: State-Trait-Anxiety-Inventory (STAI) (p < 0.0001), Multidimensional Body-Self-Relations Questionnaire (MBSRQ) (p < 0.0001) and International Physical Activity Questionnaire (IPAQ) (p = 0.004). EAT-26 scores were positively correlated with scores on STAI (ρ = 0.26, p = 0.04), MBSRQ (ρ = 0.79, p < 0.0001) and IPAQ (ρ = 0.35, p = 0.03). High scores on IPAQ and STAI were correlated with a 12.2-fold (p = 0.008) and 4.3-fold (p = 0.04) increased risk for high scores on EAT-26 respectively. Conclusions: DEBs may occur in FHA populations at a higher frequency compared to the general population. Anxiety and overweight preoccupation may underlie and independently contribute to development and maintenance of both DEBs and FHA. This evidence may have future implications for both screening and interventions that target DEBs and other psychological factors. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Συγγραφείς:
Tranoulis, A.
Soldatou, A.
Georgiou, D.
Mavrogianni, D.
Loutradis, D.
Michala, L.
Περιοδικό:
Archives of Gynecology and Obstetrics
Λέξεις-κλειδιά:
adolescent; adult; Article; behavior disorder assessment; bulimia; case control study; clinical article; controlled study; correlation coefficient; deranged eating behavior; disease predisposition; Eating Attitudes Test; eating disorder; female; functional hypothalamic amenorrhea; human; hypothalamic amenorrhea; international physical activity questionnaire; logistic regression analysis; Multidimensional Body Self Relations Questionnaire; prospective study; questionnaire; risk factor; self report; State Trait Anxiety Inventory; young adult; amenorrhea; complication; hypothalamus disease, Adolescent; Adult; Amenorrhea; Case-Control Studies; Female; Humans; Hypothalamic Diseases; Prospective Studies; Young Adult
DOI:
10.1007/s00404-020-05499-1
