Τίτλος:
Salivary inflammatory markers in tension type headache and migraine: the SalHead cohort study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To investigate the possible association between salivary CRP, IL-1β, and IL-6 levels, depression/anxiety and migraine, and tension type headache (TTH) in saliva of these patients. Method: A longitudinal prospective study was conducted on 30 migraineurs, 30 TTH patients, and 30 age-matched healthy controls. Anxiety and depression were measured by using the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Depression Inventory (BDI). Salivary IL-6, IL-1β, and CRP were collected in distinct time points as A: headache-free period, B: during headache, C: 1 day after headache attack, and measured by using ELISA kits. Results: No significant differences were found in time variation of CRP, IL-1β, and IL-6 levels between migraine and TTH (p > 0.05). IL1-β had the highest discriminative value (area under the curve = 0.924, p value < 0.001), and then CRP (area under the curve = 0.763, p value < 0.001) and IL-6 (area under the curve = 0.537, p value = 0.58). CRP and IL-6 were negatively correlated with HAM-A and BDI scores. Conclusion: IL1-β had the highest discriminative value between headache patients and controls compared with CRP and IL-6. CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups. © 2019, Fondazione Società Italiana di Neurologia.
Συγγραφείς:
Bougea, A.
Spantideas, N.
Galanis, P.
Katsika, P.
Boufidou, F.
Voskou, P.
Vamvakaris, I.
Anagnostou, E.
Nikolaou, X.
Kararizou, E.
Περιοδικό:
Neurological Sciences
Λέξεις-κλειδιά:
C reactive protein; interleukin 1beta; interleukin 6; C reactive protein; IL1B protein, human; IL6 protein, human; interleukin 1beta; interleukin 6, adult; anxiety; Article; Beck Depression Inventory; comorbidity; controlled study; depression; enzyme linked immunosorbent assay; female; Hamilton Anxiety Scale; human; inflammation; longitudinal study; major clinical study; male; migraine; prospective study; saliva level; tension headache; clinical trial; depression; immunology; inflammation; metabolism; middle aged; migraine; register; saliva; tension headache; time factor, Adult; Anxiety; C-Reactive Protein; Comorbidity; Depression; Female; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Longitudinal Studies; Male; Middle Aged; Migraine Disorders; Registries; Saliva; Tension-Type Headache; Time Factors
DOI:
10.1007/s10072-019-04151-4
