Τίτλος:
Paraoxonase-1 and Symptomatic Status in Carotid Artery Disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated hydrolase that appears to have a protective action against atherosclerosis. The aim of our study is to identify whether PON-1 levels may be associated with the manifestation of symptoms in patients with carotid artery stenosis. Methods: We studied all patients who underwent carotid endarterectomy in the Vascular Surgery Department of Laikon Hospital, Athens, Greece, from July 2012 to July 2014. Medical history was recorded and PON-1 glucose, total cholesterol, HDL cholesterol, low-density lipoprotein cholesterol, and triglycerides levels were measured. Variables were compared between symptomatic and asymptomatic patients. A receiver operating characteristic (ROC) curve was constructed to evaluate the accuracy of PON-1 to predict symptoms. Results: A total of 74 patients were included, 41 were asymptomatic and the mean age was 68.5 years. The 2 groups appear to differ significantly with regards to the PON-1 levels, with the symptomatic group showing lower levels (5.3 ± 1.19 vs. 4.6 ± 1.36 ng/mL; P = 0.025). ROC analysis demonstrated an area under the curve of 0.654 (P = 0.023). Conclusions: Reduced PON-1 levels showed a significant association with symptomatic status, which was independent of other traditional cardiovascular factors. Further studies are required to prospectively assess the role of PON-1 in predicting cerebrovascular events in patients with carotid artery disease. © 2019 Elsevier Inc.
Συγγραφείς:
Lioudaki, S.
Verikokos, C.
Kouraklis, G.
Kontopodis, N.
Markakis, G.
Ioannou, C.
Daskalopoulou, A.
Perrea, D.
Klonaris, C.
Περιοδικό:
Annals of Vascular Surgery
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
aryldialkylphosphatase 1; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; aryldialkylphosphatase; biological marker; lipid; PON1 protein, human, aged; Article; carotid atherosclerosis; carotid endarterectomy; cholesterol blood level; clinical feature; computed tomographic angiography; diagnostic accuracy; digital subtraction angiography; enzyme linked immunosorbent assay; female; Greece; human; major clinical study; male; neuroimaging; priority journal; asymptomatic disease; blood; carotid artery obstruction; comparative study; complication; cross-sectional study; down regulation; glucose blood level; middle aged, Aged; Aryldialkylphosphatase; Asymptomatic Diseases; Biomarkers; Blood Glucose; Carotid Stenosis; Cross-Sectional Studies; Down-Regulation; Endarterectomy, Carotid; Female; Humans; Lipids; Male; Middle Aged
DOI:
10.1016/j.avsg.2019.07.020
