Τίτλος:
Left Ventricular Hypertrophy and Mortality Risk in Male Veteran Patients at High Cardiovascular Risk
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Several studies addressed cardiovascular risk and mortality in the general population, but data in veteran patients is lacking. This study was designed to investigate the association between echocardiographic left ventricular hypertrophy (LVH) and all-cause mortality in a male, high-risk group of veterans. Valid echocardiograms were evaluated in 10,406 male veterans, mean age 68.3 ± 13 years. Using the left ventricular mass/body surface area (LVM/BSA) method 6,575 (63.1%) patients had normal left LVMI and 3,831 (37.9%) had LVH, defined as LVMI ≥116 g/m2. Of those 1,371 (13.2%) had mild LVH, 1,025 (9.9%) moderate LVH, 605 (5.8%) severe, and 830 (8%) had extreme LVH. After a mean follow up of 5.9 ± 4.4 years, a total of 3,550 (34.1%) patients died. Cox proportional hazard analyses adjusted for co-morbidities revealed increased risk for individuals with mild LVH (hazard ratios [HR] 1.21; 95% confidence intervals [CI]: 1.09 to 1.33); moderate LVH (HR 1.37; 95% CI: 1.23 to 1.52); severe (HR = 1.36; 95% CI: 1.19 to 1.56); and extreme LVH, (HR = 1.95; 95% CI: 1.74 to 2.17). Similar findings were observed when LVMI was defined by LVM/m2.7. When LVM index was introduced as a continuous variable, mortality risk was 6.2% higher per 10-unit change in LVMI, and 9.4% higher when defined by the m2.7 method. There was no difference in mortality risk between black and white patients, or patients with concentric or eccentric LVH. We conclude that increased LVMI was associated with increased risk of all-cause mortality. The incremental risk was significantly higher in patients with extreme LVH. © 2020
Συγγραφείς:
Papademetriou, V.
Stavropoulos, K.
Kokkinos, P.
Doumas, M.
Imprialos, K.
Thomopoulos, C.
Faselis, C.
Tsioufis, C.
Περιοδικό:
AMERICAN JOURNAL OF CARDIOLOGY
Εκδότης:
HANLEY & BELFUS-ELSEVIER INC
Λέξεις-κλειδιά:
adult; aged; all cause mortality; Article; body surface; cardiovascular risk; Caucasian; cohort analysis; comorbidity; controlled study; disease association; echocardiography; follow up; heart left ventricle hypertrophy; heart left ventricle mass; high risk patient; human; longitudinal study; major clinical study; male; middle aged; mortality risk; priority journal; veteran; cardiovascular disease; cause of death; diagnostic imaging; heart left ventricle hypertrophy; mortality; risk; United States, Aged; Cardiovascular Diseases; Cause of Death; Echocardiography; Follow-Up Studies; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Risk; United States; Veterans
DOI:
10.1016/j.amjcard.2019.12.029
