Τίτλος:
Cutaneous T-cell lymphoma: aetiopathogenesis and current diagnostic and therapeutic developments
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Cutaneous T-cell lymphoma is a heterogeneous group of non-Hodgkin’s lymphoma, characterized by an infiltration of malignant T cells in the skin. The most common subgroups include mycosis fungoides followed by the aggressive leukaemic variant, Sézary syndrome. The pathophysiology of this neoplasm is poorly understood. The diagnosis of mycosis fungoides at the early stages can be challenging due to phenotypic similarities with other skin conditions. A lack of understanding of the aetiopathology of this neoplasia makes prognosis and diagnosis, as well as the development of targeted therapies aimed at long remission, challenging. This review provides an update on the aetiopathology of cutaneous T-cell lymphoma with regards to genetic and epigenetic alterations, current diagnostic tools and treatments, as well as emerging therapies. © 2020, JLE/Springer.
Συγγραφείς:
Papadaki, M.
Saraki, K.
Karagianni, F.
Piperi, C.
Papadavid, E.
Περιοδικό:
European Journal of Dermatology
Εκδότης:
John Libbey Eurotext
Λέξεις-κλειδιά:
alemtuzumab; brentuximab vedotin; bromodomain containing protein 9; chemokine receptor CCR4; chromodomain helicase dna binding protein 3; cyclic AMP responsive element binding protein binding protein; histone deacetylase; histone lysine n methyltransferase 2d; interleukin 15; interleukin 2; interleukin 4; interleukin 5; lacutamab; long untranslated RNA; lysine methyltransferase 2c; microRNA; mogamulizumab; peptides and proteins; romidepsin; STAT protein; T lymphocyte receptor; tet methylcytosine dioxygenase 2; transcription activator brg1 protein; unclassified drug; vorinostat, antigenicity; apoptosis; cancer growth; carcinogenesis; cell cycle; cutaneous T cell lymphoma; DNA damage response; DNA methylation; DNA repair; epigenetics; gene expression; gene mutation; high throughput sequencing; histone acetylation; human; JAK/STAT signaling; MAPK signaling; nonhuman; pathogenesis; Review; signal transduction
DOI:
10.1684/ejd.2020.3712
